Induction of tumor necrosis factor-alpha and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine.
The findings provide new insights into the mechanism of gastric injury caused by NSAIDs and show that ebrotidine protection against indomethacin-induced mucosal damage occurs through the inhibition of epithelial cell apoptosis triggered by the enhancement in the mucosal TNF-alpha expression.
Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to β-adrenergic G-protein-coupled receptor activation
The findings underline the role of EGFR as a convergence point in modulation of salivary mucin secretion triggered by β-adrenergic agonist GPCR activation and demonstrate the importance of Src kinase in the EGFR transactivation process.
Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury.
- S. Konturek, T. Brzozowski, J. Majka, A. Dembiński, A. Slomiany, B. Slomiany
- Medicine, BiologyScandinavian Journal of Gastroenterology
- 1 August 1992
Pretreatment with indomethacin decreased in part the protection by TGF and EGF against ethanol-induced damage and virtually abolished the protective action of these peptides against stress-induced injury.
Effect of antiulcer agents on the physicochemical properties of gastric mucus.
- B. Slomiany, V. Murty, J. Piotrowski, A. Slomiany
- BiologySymposia of the Society for Experimental Biology
The data on gastric mucus gel, following prolonged administration, show that these drugs enhance the lipid content of the mucUS gel, and increase both the mucus coat dimension and the proportion of the high molecular weight form of its mucin component, which result in the improvement of viscoelastic, permselective and hydrophobic properties of gastrics mucus.
Inhibition of gastric mucosal laminin receptor by Helicobacter pylori lipopolysaccharide: effect of nitecapone.
Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents
- J. Piotrowski, E. Piotrowski, D. Skrodzka, A. Slomiany, B. Slomiany
- MedicineBiochemistry and molecular biology international
- 1 June 1997
The results demonstrate that ethanol‐induced gastric epithelial cells apoptosis triggered by the enhancement in mucosal TNF‐α is efficiently counteracted by ebrotidine.
Role of endothelin-1 and constitutive nitric oxide synthase in gastric mucosal resistance to indomethacin injury: effect of antiulcer agents.
It is suggested that an increase in the vasoconstrictive ET-1 level combined with a decrease in regulatory cytokine, IL-4, and a loss of compensatory action by cNOS may be responsible for the gastric mucosal injury caused by indomethacin.
Isolation and structural studies of sulfated glycoproteins of hog gastric mucosa.
Structures of the neutral oligosaccharides isolated from A-active human gastric mucin.