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SYK protein, human

Known as: 2.7.1.112, PTK72, Tyrosine-Protein Kinase SYK 
Tyrosine-protein kinase SYK (635 aa, ~72 kDa) is encoded by the human SYK gene. This protein plays a role in tyrosine phosphorylation, receptor… 
National Institutes of Health

Related topics

Related topics

18 relations
B Cell Receptor Signaling PathwayB-Cell ActivationCalcium SignalingCell Differentiation process

Broader (1)

Syk kinase

Papers overview

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Highly Cited
2005
Highly Cited
2005
Rapid ubiquitination of Syk following GPVI activation in platelets.
Spleen tyrosine kinase (Syk) activation is a key intermediate step in the activation of platelets by the physiologic agonist… 
Highly Cited
1998
Highly Cited
1998
Stimulation of Src Family Protein-tyrosine Kinases as a Proximal and Mandatory Step for SYK Kinase-dependent Phospholipase Cγ2 Activation in Lymphoma B Cells Exposed to Low Energy Electromagnetic…
Here, we present evidence that exposure of DT40 lymphoma B cells to low energy electromagnetic field (EMF) results in a tyrosine… 
1997
1997
Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk.
The two related protein-tyrosine kinases Syk and Zap are rapidly phosphorylated on tyrosine residues and enzymatically activated… 
Highly Cited
1996
Highly Cited
1996
Syk-dependent Phosphorylation of Shc
Antigen receptors on T- and B-cells activate Ras through a signaling pathway that results in the tyrosine phosphorylation of Shc… 
Highly Cited
1995
Highly Cited
1995
Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells
In mast cells, antigen-mediated aggregation of the high-affinity receptor for immunoglobulin E, Fc epsilon RI, stimulates… 
1994
1994
Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells.
Proteins that bind to discrete domains of the Blk, Fyn, Lyn, and Btk protein tyrosine kinases were examined in pre-B cells that… 
Highly Cited
1993
Highly Cited
1993
Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins.
Cross-linking membrane Ig (mIg) on B cells stimulates tyrosine phosphorylation of proteins involved in signal transduction… 
Highly Cited
1993
Highly Cited
1993
B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn
Highly Cited
1991
Highly Cited
1991
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase.
1987
1987
Isolation of temperature-sensitive tyrosine kinase mutants of v-abl oncogene by screening with antibodies for phosphotyrosine.
Temperature-sensitive protein-tyrosine kinase (EC 2.7.1.112) mutants of the oncogene v-abl have been obtained by a direct… 
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