SYK protein, human

Known as: 2.7.1.112, PTK72, Tyrosine-Protein Kinase SYK 
Tyrosine-protein kinase SYK (635 aa, ~72 kDa) is encoded by the human SYK gene. This protein plays a role in tyrosine phosphorylation, receptor… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The C-type lectin dectin-1 activates the transcription factor NF-κB through a Syk kinase–dependent signaling pathway to induce… (More)
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Highly Cited
2008
Highly Cited
2008
Peripheral T-cell lymphomas (PTCLs) are fatal in the majority of patients and novel treatments, such as protein tyrosine kinase… (More)
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Highly Cited
2006
Highly Cited
2006
The mammalian target of rapamycin (mTOR) is emerging as a promising target for antitumor therapy. However, the mechanism that… (More)
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Highly Cited
2006
Highly Cited
2006
Among B-cell lymphomas mantle cell lymphoma (MCL) has the worst prognosis. By using a combination of genomic and expression… (More)
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Highly Cited
2003
Highly Cited
2003
Although it is well established that reactive oxygen intermediates mediate the NF-kappaB activation induced by most agents, how… (More)
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Highly Cited
2002
Highly Cited
2002
P-selectin glycoprotein ligand 1 (PSGL-1) is a leukocyte adhesion molecule involved in cell tether and rolling on activated… (More)
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Review
2000
Review
2000
The tyrosine kinase SYK plays critical roles in signalling through immune receptors. Gene-targeting studies have identified the… (More)
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Highly Cited
1999
Highly Cited
1999
We have recently demonstrated that the D3-phosphoinositide phosphatidylinositol 3,4,5-trisphosphate (PtdIns-3,4,5-P(3)) is… (More)
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Highly Cited
1997
Highly Cited
1997
Receptors on macrophages for the Fc region of IgG (FcgammaR) mediate a number of responses important for host immunity. Signaling… (More)
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Highly Cited
1991
Highly Cited
1991
Activation of platelets with thrombin and other agonists causes a rapid increase in the phosphorylation of multiple proteins on… (More)
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