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Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.
PURPOSE To define more uniform criteria for risk-based treatment assignment for children with acute lymphoblastic leukemia (ALL), the Cancer Therapy Evaluation Program (CTEP) of the National CancerExpand
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Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.
A novel homology model of the kinase domain of Janus kinase (JAK) 3 was used for the structure-based design of dimethoxyquinazoline compounds with potent and specific inhibitory activity againstExpand
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Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.
  • L. Sun, P. Goodman, +12 authors F. Uckun
  • Biology, Medicine
  • Journal of clinical oncology : official journal…
  • 1 December 1999
PURPOSE We sought to determine if molecular abnormalities involving the Ikaros gene could contribute to the development of acute lymphoblastic leukemia (ALL) in children. PATIENTS AND METHODS WeExpand
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Crystal Structure of Bruton's Tyrosine Kinase Domain Suggests a Novel Pathway for Activation and Provides Insights into the Molecular Basis of X-linked Agammaglobulinemia*
Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in the humanExpand
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Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
  • L. Sun, N. Heerema, +6 authors F. Uckun
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 January 1999
Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development, and germline mutant mice that express only non-DNA binding dominant-negative "leukemogenic" IkarosExpand
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Exposure of B-lineage Lymphoid Cells to Low Energy Electromagnetic Fields Stimulates Lyn Kinase (*)
Here, we present evidence that exposure of B-lineage lymphoid cells to low energy electromagnetic fields (EMF) stimulates the protein tyrosine kinases Lyn and Syk, results in tyrosine phosphorylationExpand
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Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.
  • L. Sun, M. Crotty, +10 authors F. Uckun
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 1 August 1999
Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development. Germ-line mutant mice that express only non-DNA binding dominant-negative "leukemogenic" IkarosExpand
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Bruton’s Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex*
Bruton’s tyrosine kinase (BTK) is a member of the Src-related Tec family of protein tyrosine kinases. Mutations in the btk gene have been linked to severe developmental blocks in human B-cellExpand
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Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group.
PURPOSE Infants represent a very poor risk group for acute lymphoblastic leukemia (ALL). We report treatment outcome for such patients treated with intensive therapy on consecutive Children's CancerExpand
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Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group.
PURPOSE Nonrandom chromosomal translocations are frequently observed in pediatric patients with acute lymphoblastic leukemia (ALL). Specific translocations, such as t(4;11) and t(9;22), identifyExpand
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