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Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.
The more uniform approach to risk-based treatment assignment and to collection of specific prognostic factors should increase the efficiency of future ALL clinical research.
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.
A novel homology model of the kinase domain of Janus kinase (JAK) 3 was used for the structure-based design of dimethoxyquinazoline compounds with potent and specific inhibitory activity against JAK3, and derivatives of this compound that contain an OH group at the 4' position of the phenyl ring may provide the new treatment strategies for the design of childhood treatment strategies.
Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.
  • L. Sun, P. Goodman, +12 authors F. Uckun
  • Biology, Medicine
    Journal of clinical oncology : official journal…
  • 1 December 1999
Leukemic cells from ALL patients, in contrast to normal lymphocyte precursors, express high levels of non- DNA-binding Ikaros isoforms that are reminiscent of the non-DNA-bindingIkarosisoforms that lead to lymphoblastic leukemia in mice.
Crystal Structure of Bruton's Tyrosine Kinase Domain Suggests a Novel Pathway for Activation and Provides Insights into the Molecular Basis of X-linked Agammaglobulinemia*
The x-ray crystal structure of the Bruton's tyrosine kinase kinase domain in its unphosphorylated state to a 2.1 Å resolution is determined and a comparison with the structures of other tyosine kinases is provided.
Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group.
Treatment outcome for infants with newly diagnosed ALL treated with intensive therapy on consecutive Children's Cancer Group protocols improved, indicating that intrathecal chemotherapy combined with very-high-dose systemic therapy provides adequate protection of the CNS.
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
  • L. Sun, N. Heerema, +6 authors F. Uckun
  • Biology, Medicine
    Proceedings of the National Academy of Sciences…
  • 19 January 1999
The results implicate the expression of dominant-negative Ikaros isoforms and the disruption of normal IkarOS function in the leukemogenesis of ALL in infants.
Exposure of B-lineage Lymphoid Cells to Low Energy Electromagnetic Fields Stimulates Lyn Kinase (*)
Results indicate that activation of Lyn kinase is sufficient and mandatory for EMF-induced tyrosine phosphorylation in B-lineage lymphoid cells.
Bruton’s Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex*
The ability of BTK to inhibit the pro-apoptotic effects of Fas ligation prompts the hypothesis that apoptosis of developing B-cell precursors during normal B- cell ontogeny may be reciprocally regulated by Fas and BTK.
Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes
Evidence is provided that the tyrosine kinase inhibitor herbimycin A and the free radical scavenger N-acetyl-cysteine inhibit both radiation-induced and H2O2-induced activation of NF-kappa B, indicating that activation triggered by ROI is dependent on tyrosin kinase activity.
Clinical development of microbicides for the prevention of HIV infection.
The HIV/AIDS pandemic continues its spread at a rate of over 15,000 new infections every day and current efforts are aimed at developing intravaginal/intrarectal topical formulations of anti-HIV agents or microbicides to curb the mucosal and perinatal HIV transmission.