Rapid ubiquitination of Syk following GPVI activation in platelets.

@article{Dangelmaier2005RapidUO,
  title={Rapid ubiquitination of Syk following GPVI activation in platelets.},
  author={Carol A. Dangelmaier and Patricia G. Quinter and Jianguo Jin and Alexander Y Tsygankov and Satya P Kunapuli and J. Lindner Daniel},
  journal={Blood},
  year={2005},
  volume={105 10},
  pages={
          3918-24
        }
}
Spleen tyrosine kinase (Syk) activation is a key intermediate step in the activation of platelets by the physiologic agonist collagen. We have found that Syk is rapidly ubiquitinated upon activation of platelets by collagen, collagen-related peptide (CRP), and convulxin. The Src family kinase inhibitors prevented Syk phosphorylation and its ubiquitination, indicating that the process is downstream of Src kinases. The ubiquitination of Syk did not cause degradation of the protein as evidenced by… CONTINUE READING

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