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Interferon-gamma: an overview of signals, mechanisms and functions.
TLDR
The current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophages function during infection are reviewed.
Interferon‐γ: an overview of signals, mechanisms and functions
TLDR
The current understanding of IFN‐γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophages function during infection are reviewed.
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
TLDR
A model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS) is suggested.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
TLDR
MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle–Wells syndrome, and is a potential therapeutic for NLRP3-associated syndromes, and a tool for further study of theNLRP3 inflammasome in human health and disease.
The regulated retrotransposon transcriptome of mammalian cells
TLDR
It is reported that 6–30% of cap-selected mouse and human RNA transcripts initiate within repetitive elements, and it is concluded that retrotransposon transcription has a key influence upon the transcriptional output of the mammalian genome.
The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
TLDR
It is proposed that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.
Tiny RNAs associated with transcription start sites in animals
TLDR
These tiny RNAs with a modal length of 18 nt that map within −60 to +120 nt of transcription start sites (TSSs) in human, chicken and Drosophila suggest that tiRNAs may be a general feature of transcription in metazoa and possibly all eukaryotes.
Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo1
TLDR
It is demonstrated that OsteoMacs are an integral component of bone tissues and play a novel role in bone homeostasis through regulating osteoblast function and implicate OsteiMacs, in addition to osteoclasts and osteoblasts, as principal participants in bone dynamics.
The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans1
TLDR
Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans.
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