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Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells
The extracellular functions of galectin-7 (p53-induced gene 1) are largely unknown. On the surface of neuroblastoma cells (SK-N-MC), the increased GM1 density, a result of upregulated gangliosideExpand
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Multivalent Carbohydrate Recognition on a Glycodendrimer‐Functionalized Flow‐Through Chip
Dendrimers were fitted out with up to eight mannose moieties by “click” chemistry. They were subsequently attached to aluminum oxide chips via a spacer that was linked to the dendrimer core; thisExpand
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Inhibition of P-fimbriated Escherichia coli adhesion by multivalent galabiose derivatives studied by a live-bacteria application of surface plasmon resonance.
OBJECTIVES Uropathogenic P-fimbriated Escherichia coli adheres to host cells by specific adhesins recognizing galabiose (Galalpha1-4Gal)-containing structures on cell surfaces. In search of agentsExpand
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Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray
Multivalency is an important phenomenon in protein–carbohydrate interactions. In order to evaluate glycodendrimers as multivalent inhibitors of carbohydrate binding proteins, we displayed them on aExpand
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Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1.
Inhibitors for galectin-1 and -3 were synthesized from thiodigalactoside and lactosamine by derivatization of the galactose C3. Introduction of 4-phenyl-1H-1,2,3-triazol-1-yl substituents at theExpand
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Mutation of Tyrosine Residues Involved in the Alkylation Half Reaction of Epoxide Hydrolase from Agrobacterium radiobacter AD1 Results in Improved Enantioselectivity
Enantiomerically pure epoxides (oxiranes) are uniquely suited building blocks for synthetic purposes.1 Such epoxides are often prepared by means of remarkably effective synthetic catalysts.2 ThereExpand
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Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA.
The synthesis of a new rigid spacer based on carbohydrate-triazole repeating units and their incorporation into divalent systems is described. Inhibition studies showed that a well-matched systemExpand
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Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli
A series of multivalent mannose containing compounds were prepared varying in size from small divalent, to 16-valent glycodenrimers and 21-valent glycopolymers. The molecules were approached via aExpand
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Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA.
Multivalent galactosides inhibiting Pseudomonas aeruginosa biofilms may help control this problematic pathogen. To understand the binding mode of tetravalent glycopeptide dendrimer GalAG2Expand
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