SYK gene

Known as: SYK, PROTEIN-TYROSINE KINASE SYK, SPLEEN TYROSINE KINASE 
This gene plays a role in receptor tyrosine phosphorylation signal transduction, phagocytosis, endothelial cell growth and proliferation.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
B cell receptor (BCR) signaling pathway components represent promising treatment targets in diffuse large B cell lymphoma (DLBCL… (More)
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Highly Cited
2012
Highly Cited
2012
Syk is a protein tyrosine kinase that couples B-cell receptor (BCR) activation with downstream signaling pathways, affecting cell… (More)
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Highly Cited
2011
Highly Cited
2011
In this study, we have addressed how Lyn kinase signaling mediates nilotinib-resistance by quantitative phospho-proteomics using… (More)
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Highly Cited
2011
Highly Cited
2011
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, and the role of SYK in its pathogenesis is… (More)
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Highly Cited
2010
Highly Cited
2010
The microenvironment provides essential growth and survival signals to chronic lymphocytic leukemia (CLL) cells and contributes… (More)
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Highly Cited
2009
Highly Cited
2009
Injury or impaired clearance of apoptotic cells leads to the pathological accumulation of necrotic corpses, which induce an… (More)
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Highly Cited
2008
Highly Cited
2008
The role of B-cell receptor (BCR)-mediated survival signals in diffuse large B-cell lymphoma (DLBCL) remains undefined. Ligand… (More)
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Highly Cited
2007
Highly Cited
2007
Engagement of neutrophils by E-selectin results in integrin activation. Here, we investigated primary mouse neutrophils in whole… (More)
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Highly Cited
2006
Highly Cited
2006
Among peripheral T-cell lymphomas (PTCL), the heterogeneous category of unspecified PTCL represents the most common subtype… (More)
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Highly Cited
2001
Highly Cited
2001
A number of cancer-associated genes have been shown to be inactivated by hypermethylation of CpG islands during breast… (More)
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