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Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to β-adrenergic G-protein-coupled receptor activation
TLDR
The findings underline the role of EGFR as a convergence point in modulation of salivary mucin secretion triggered by β-adrenergic agonist GPCR activation and demonstrate the importance of Src kinase in the EGFR transactivation process.
Effect of antiulcer agents on the physicochemical properties of gastric mucus.
TLDR
The data on gastric mucus gel, following prolonged administration, show that these drugs enhance the lipid content of the mucUS gel, and increase both the mucus coat dimension and the proportion of the high molecular weight form of its mucin component, which result in the improvement of viscoelastic, permselective and hydrophobic properties of gastrics mucus.
Role of endothelin-1 and constitutive nitric oxide synthase in gastric mucosal resistance to indomethacin injury: effect of antiulcer agents.
TLDR
It is suggested that an increase in the vasoconstrictive ET-1 level combined with a decrease in regulatory cytokine, IL-4, and a loss of compensatory action by cNOS may be responsible for the gastric mucosal injury caused by indomethacin.
Helicobacter pylori-induced gastric mucosal TGF-α ectodomain shedding and EGFR transactivation involves Rac1/p38 MAPK-dependent TACE activation
TLDR
It is demonstrated that up-regulation in H. pylori LPS-elicited Rac1-GTP membrane translocation plays a pivotal role in recruitment of the activated p38 to the membrane for TACE activation through phosphorylation on Thr735.
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