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Sterol Biosynthesis Pathway

Known as: Sterol Biosynthesis, sterol formation, sterol synthesis 
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in… 
National Institutes of Health

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6 relations
17-Beta-Hydroxysteroid Dehydrogenase 7HMGCR protein, humanHSD17B7 wt AlleleNAD(P)H dehydrogenase (quinone) 1, human

Papers overview

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Highly Cited
1997
Highly Cited
1997
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Pharmacological properties of NK-104 ((+)-monocalcium bis¿(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl++ +]-3,5… 
Highly Cited
1983
Highly Cited
1983
Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors.
These studies were undertaken to measure rates of synthesis of digitonin-precipitable sterols in vivo and in vitro in control… 
Highly Cited
1979
Highly Cited
1979
Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures.
A method is described for the measurement of [‘“Clacetate incorporation into dolichol in cultured mammalian cells. In various… 
Highly Cited
1977
Highly Cited
1977
Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition.
When cell cultures were incubated with certain oxygenated derivatives of cholesterol which specifically depress 3-hydroxy-3… 
Highly Cited
1977
Highly Cited
1977
Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes
The rate of cholesterol synthesis from [14C]acetate was low in circulating blood lymphocytes freshly isolated from 17 normal… 
Highly Cited
1977
Highly Cited
1977
Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.
Highly Cited
1977
Highly Cited
1977
Binding, internalization, and degradation of high density lipoprotein by cultured normal human fibroblasts.
Comparative studies were made of the metabolism of plasma high density lipoprotein (HDL) and low density lipoprotein (LDL) by… 
Highly Cited
1977
Highly Cited
1977
Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton.
Highly Cited
1975
Highly Cited
1975
Regulation of sterol synthesis in cultured cells by oxygenated derivatives of cholesterol
Sterol synthesis in liver in vivo is regulated at the site of the reaction catalyzed by 3‐hydroxy‐3‐methylglutaryl‐CoA reductase… 
Highly Cited
1969
Highly Cited
1969
Regulation of sterol synthesis in developing brains of normal and jimpy mice.
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