Sterol Biosynthesis Pathway

Known as: Sterol Biosynthesis, sterol formation, sterol synthesis 
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in… (More)
National Institutes of Health

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17-Beta-Hydroxysteroid Dehydrogenase 7HMGCR protein, humanHSD17B7 wt AlleleNAD(P)H dehydrogenase (quinone) 1, human
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We… (More)
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Highly Cited
2011
Highly Cited
2011
Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis
Little is known about the protective role of inflammatory processes in modulating lipid metabolism in infection. Here we report… (More)
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Highly Cited
2010
Highly Cited
2010
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.
Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and… (More)
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Highly Cited
2004
Highly Cited
2004
A link between sterol biosynthesis, the cell wall, and cellulose in Arabidopsis.
A crucial role for sterols in plant growth and development is underscored by the identification of three Arabidopsis sterol… (More)
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Highly Cited
2003
Highly Cited
2003
Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus.
Sterol biosynthesis is viewed primarily as a eukaryotic process, and the frequency of its occurrence in bacteria has long been a… (More)
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Highly Cited
2001
Highly Cited
2001
Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae.
Sterol levels affect the expression of many genes in yeast and humans. We found that the paralogous transcription factors Upc2p… (More)
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Highly Cited
2001
Highly Cited
2001
HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus.
The mechanism by which human immunodeficiency virus (HIV) protease inhibitor therapy adversely induces lipodystrophy and… (More)
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Review
1997
Review
1997
Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites.
Inhibitors of sterol and phospholipid biosynthesis in kinetoplastid parasites such as Trypanosoma cruzi, the causative agent of… (More)
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Highly Cited
1992
Highly Cited
1992
Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.
Some bisphosphonates used for the treatment of bone disorders are also potent inhibitors of squalene synthase, a critical enzyme… (More)
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Highly Cited
1983
Highly Cited
1983
Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat.
This study was undertaken to measure and compare the rates at which digitonin-precipitable sterols (DPS) were synthesized in vivo… (More)
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