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Low Density Lipoprotein Oxidation and Its Pathobiological Significance*
  • D. Steinberg
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 22 August 1997
Background The fact that low density lipoprotein (LDL) is extremely susceptible to oxidative damage has been known for some time (1, 2), but until quite recently this was primarily a nuisance for theExpand
Role of oxidized low density lipoprotein in atherogenesis.
These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications. Expand
Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.
A complex process in which endothelial cells modify LDL by mechanisms involving generation of free radicals and action of phospholipase (s) is suggested, including degradation of phosphatidylcholine. Expand
Low density lipoprotein undergoes oxidative modification in vivo.
Three mutually supportive lines of evidence for oxidation of LDL in vivo are presented and autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera. Expand
Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.
Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidativelyExpand
Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein.
Although the surface expression of MS/CD68 at steady-state represents only a small percentage of their total cellular content, these proteins can play a significant role in oxidized LDL uptake by activated macrophages in vitro and could contribute to foam cell formation in atherosclerotic lesions. Expand
The oxidative modification hypothesis of atherogenesis: an overview.
The strengths and weaknesses of each line of evidence are discussed, try to identify areas in which further research is needed, assess the relevance of the hypothesis to the human disease, and point to some of the potential targets for therapy. Expand
The LDL modification hypothesis of atherogenesis: an update Published, JLR Papers in Press, November 15, 2009.
  • D. Steinberg
  • Biology, Medicine
  • Journal of Lipid Research
  • 1 April 2009
This review summarizes the lines of evidence on which the hypothesis of oxidative modification of LDL plays an important role in the pathogenesis of atherosclerosis in animal models, its strengths, and its weaknesses. Expand
Studies on the synthesis and secretion of serum lipoproteins by rat liver slices.
The present experiments were undertaken in order to define an in vitro system in which lipoprotein biosynthesis could be studied without the many complicating variables encountered in whole-animal studies. Expand