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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information
A novel protein superfamily with over 600 members was discovered by iterative profile searches and analyzed with powerful bioinformatics and information visualization methods. Evidence exists thatExpand
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HDL-targeted therapies: progress, failures and future
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol (HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that HDL isExpand
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Learning of visceral and glandular responses.
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Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1.
Apolipoprotein A-I (apoA-I) and an apoA-I peptide mimetic removed seeding molecules from human low density lipoprotein (LDL) and rendered the LDL resistant to oxidation by human artery wall cells.Expand
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Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B
Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes, including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. & Shenk, T. (1998) Proc.Expand
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Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension.
The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raisedExpand
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Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis.
  • N. Miller
  • Medicine
  • American heart journal
  • 1 February 1987
Prospective studies in several countries have demonstrated an inverse association between incidence of ischemic heart disease (IHD) and high-density lipoprotein (HDL) cholesterol concentration.1~2 ItExpand
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A sandwich enzyme-linked immunosorbent assay for human serum paraoxonase concentration.
Serum paraoxonase (PON) is associated with plasma high density lipoproteins, and prevents the oxidative modification of low density lipoproteins. We have developed a sensitive sandwich enzyme-linkedExpand
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Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins.
The relation of coronary artery disease to plasma lipoproteins was examined in 104 men aged 35-65 years undergoing coronary angiography for suspected myocardial ischaemia. A score reflecting theExpand
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Elevation of Plasma High-Density Lipoprotein Concentration Reduces Interleukin-1–Induced Expression of E-Selectin in an In Vivo Model of Acute Inflammation
Background—Although there is strong evidence that plasma HDL levels correlate inversely with the incidence of coronary artery disease, the precise mechanism(s) for the protective effect of HDLsExpand
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