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HMGCR protein, human

Known as: 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, human, HMG-CoA Reductase 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (888 aa, ~97 kDa) is encoded by the human HMGCR gene. This protein is involved in cholesterol… 
National Institutes of Health

Related topics

Related topics

14 relations
Atorvastatin SodiumAtorvastatin calciumCholesterol HomeostasisEnzyme Gene

Broader (2)

Hydroxymethylglutaryl coenzyme A reductaseHydroxymethylglutaryl-CoA reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice
Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of… 
2016
2016
Regulation of the Lactobacillus Strains on HMGCoA Reductase Gene Transcription in Human HepG2 Cells via Nuclear Factor-κB.
Lactic acid bacteria have been identified to be effective in reducing cholesterol levels. Most of the mechanistic studies were… 
Review
2014
Review
2014
Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: highlights from animal studies.
2012
2012
Effect of HMGCR Variant Alleles on Low‐Density Lipoprotein Cholesterol—Lowering Response to Atorvastatin in Healthy Korean Subjects
The investigators quantified the relationship between the genetic polymorphism of HMGCR (3‐hydroxy‐3‐methylglutaryl coenzyme A… 
2003
2003
Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade.
Diverse forms of injury cause proximal tubular cholesterol accumulation. However, underlying mechanisms in general, and those… 
1991
1991
Cholesterol metabolism in hypercholesterolemia-resistant rabbits.
1981
1981
Hormonal regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and alkaline phosphatase in cultured intestinal mucosa.
1979
1979
Two major regulatory steps in cholesterol synthesis by human renal cancer cells.
Highly Cited
1975
Highly Cited
1975
Sterol balance studies in the rat. Effects of dietary cholesterol and beta-sitosterol on sterol balance and rate-limiting enzymes of sterol metabolism.
Highly Cited
1974
Highly Cited
1974
Effects of clofibrate on sterol metabolism in the rat.
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