HMGCR protein, human

Known as: 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, human, HMG-CoA Reductase 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (888 aa, ~97 kDa) is encoded by the human HMGCR gene. This protein is involved in cholesterol… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
BACKGROUND Pharmacologic inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) are being evaluated in clinical… (More)
Is this relevant?
2015
2015
De novo lipogenesis, a hallmark for cancers is required for cellular transformation. Further it is believed that resistance to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2014
Highly Cited
2014
Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
2014
2014
3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting enzyme in the cholesterol biosynthesis pathway… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2013
Review
2013
3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the target of the statins, important drugs that lower blood cholesterol… (More)
Is this relevant?
Review
2013
Review
2013
Statins are among the most commonly prescribed medications that significantly reduce cardiovascular risk in selected individuals… (More)
Is this relevant?
2010
2010
Elevated thyroid-stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
UNLABELLED Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2008
2008
BACKGROUND Considerable interindividual variation exists in cholesterol-lowering response to 3-hydroxy-3-methylglutaryl coenzyme… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
2007
2007
The insulin signaling pathway has been implicated in several physiological and developmental processes. In mammals, it controls… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?