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Hydroxymethylglutaryl coenzyme A reductase

Known as: Hydroxymethylglutaryl-Coenzyme A Reductase (NADP), 3-Hydroxy-3-methylglutaryl-coenzyme A reductase, NADP-dependent, Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent 
Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of this class are involved in cholesterol biosynthesis.
National Institutes of Health

Related topics

Related topics

11 relations
3-hydroxy-3-methylglutaryl coenzyme A reductase activityHMGCR geneIn BloodProcess of secretion
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Narrower (2)

HMGCR protein, humanHMGR protein, Arabidopsis

Broader (1)

Hydroxymethylglutaryl-CoA reductase

Papers overview

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Highly Cited
2003
Highly Cited
2003
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.
BACKGROUND Hesperetin is a naturally occurring flavonoid that has hypolipidemic properties. METHODS Male rats were fed a 1 g… Expand
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Highly Cited
2001
Highly Cited
2001
Effect of Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors on the Progression of Calcific Aortic Stenosis
Background—Recent studies have supported the hypothesis that calcific aortic stenosis is the product of an active inflammatory… Expand
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Highly Cited
2001
Highly Cited
2001
Improvement of Left Ventricular Remodeling and Function by Hydroxymethylglutaryl Coenzyme A Reductase Inhibition With Cerivastatin in Rats With Heart Failure After Myocardial Infarction
Background—Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) attenuate angiotensin II-induced cellular signaling… Expand
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Highly Cited
2001
Highly Cited
2001
Induction of NAD(P)H Oxidase by Oxidized Low-Density Lipoprotein in Human Endothelial Cells: Antioxidative Potential of Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor Therapy
Background—Elevated oxidative stress and superoxide anion formation in vascular cells could promote conversion of LDL to… Expand
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Highly Cited
2001
Highly Cited
2001
Cerivastatin, a Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor, Improves Endothelial Function in Elderly Diabetic Patients Within 3 Days
Background— The short-term effects of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) on endothelial function at… Expand
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Highly Cited
2001
Highly Cited
2001
Correlation of non-high-density lipoprotein cholesterol with apolipoprotein B: effect of 5 hydroxymethylglutaryl coenzyme A reductase inhibitors on non-high-density lipoprotein cholesterol levels.
Apolipoprotein B has been shown to be a better predictor of coronary heart disease than low-density lipoprotein (LDL) cholesterol… Expand
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Highly Cited
1997
Highly Cited
1997
A new nomenclature for the aldo-keto reductase superfamily.
The aldo-keto reductases (AKRs) represent a growing oxidoreductase superfamily. Forty proteins have been identified and… Expand
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Highly Cited
1997
Highly Cited
1997
Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters
Oryzanol is a class of nonsaponifiable lipids of rice bran oil (RBO). More specifically, oryzanol is a group of ferulic acid… Expand
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Highly Cited
1990
Highly Cited
1990
Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol.
BACKGROUND Inhibitors of the rate-limiting enzyme of cholesterol biosynthesis, 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA… Expand
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Highly Cited
1987
Highly Cited
1987
Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver.
The possibility that the serum concentrations of various cholesterol precursors may reflect the activity of the hepatic HMG-CoA… Expand
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