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Hydroxymethylglutaryl coenzyme A reductase

Known as: Hydroxymethylglutaryl-Coenzyme A Reductase (NADP), 3-Hydroxy-3-methylglutaryl-coenzyme A reductase, NADP-dependent, Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent 
Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of this class are involved in cholesterol biosynthesis.
National Institutes of Health

Related topics

Related topics

11 relations
3-hydroxy-3-methylglutaryl coenzyme A reductase activityHMGCR geneIn BloodProcess of secretion

Narrower (2)

HMGCR protein, humanHMGR protein, Arabidopsis

Broader (1)

Hydroxymethylglutaryl-CoA reductase

Papers overview

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2014
2014
Hypolipidemic and antioxidant activity of ethanolic extract of Symplocos racemosa Roxb. in hyperlipidemic rats: an evidence of participation of oxidative stress in hyperlipidemia.
Hypolipidemic and antioxidant activity profiles of ethanolic extracts of Symplocos racemosa (EESR) were studied by triton-WR1339… 
2004
2004
Effects of inhibitors of hydroxymethylglutaryl coenzyme A reductase on coenzyme Q and dolichol biosynthesis
SummaryInhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density… 
Highly Cited
1999
Highly Cited
1999
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes.
There is no consensus whether hepatic lipid regulatory enzymes play primary or secondary roles in cholesterol cholelithiasis. We… 
Review
1990
Review
1990
Ribonucleotide reductases: amazing and confusing.
Highly Cited
1990
Highly Cited
1990
Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
Under most experimental conditions, the activities of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA reductase) and cholesterol 7… 
Highly Cited
1988
Highly Cited
1988
Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rat
Bile acid synthesis is thought to be regulated by a negative feedback mechanism which is presumably dependent upon the flux of… 
Highly Cited
1988
Highly Cited
1988
Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin.
In the normal fed rat, both 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase and HMG-CoA reductase are found in high… 
Highly Cited
1986
Highly Cited
1986
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.
We here report the isolation and nucleotide sequencing of a full-length 3.3-kilobase cDNA for the cytoplasmic form of 3-hydroxy-3… 
Highly Cited
1977
Highly Cited
1977
Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities.
Short- and long-term effects of ethanol on HMG-CoA reductase (EC 1.1.1.34) and cholesterol 7alpha-hydroxylase activities in rat… 
1974
1974
An inhibitor of sterol biosynthesis present in cow's milk.
RECENT evidence indicates that sterol biosynthesis from acetate, but not from mevalonate, increases several-fold in the… 
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