P. Hylemon

Publications355
h-index66
Citations15,747
Highly Influential Citations622
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Bile salt biotransformations by human intestinal bacteria Published, JLR Papers in Press, November 18, 2005.
Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels in the enterohepatic circulation of some individuals and may contribute to the pathogenesis of colon… Expand
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Bile acids as regulatory molecules
In the past, bile acids were considered to be just detergent molecules derived from cholesterol in the liver. They were known to be important for the solubilization of cholesterol in the gallbladder… Expand
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Altered profile of human gut microbiome is associated with cirrhosis and its complications.
BACKGROUND & AIMS The gut microbiome is altered in cirrhosis; however its evolution with disease progression is only partly understood. We aimed to study changes in the microbiome over cirrhosis… Expand
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Linkage of gut microbiome with cognition in hepatic encephalopathy.
Hepatic encephalopathy (HE) has been related to gut bacteria and inflammation in the setting of intestinal barrier dysfunction. We aimed to link the gut microbiome with cognition and inflammation in… Expand
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Bile acids and the gut microbiome
Purpose of review We examine the latest research on the emerging bile acid-gut microbiome axis and its role in health and disease. Our focus revolves around two key microbial pathways for degrading… Expand
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Modulation of the Metabiome by Rifaximin in Patients with Cirrhosis and Minimal Hepatic Encephalopathy
Hepatic encephalopathy (HE) represents a dysfunctional gut-liver-brain axis in cirrhosis which can negatively impact outcomes. This altered gut-brain relationship has been treated using gut-selective… Expand
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Consequences of bile salt biotransformations by intestinal bacteria
ABSTRACT Emerging evidence strongly suggest that the human “microbiome” plays an important role in both health and disease. Bile acids function both as detergents molecules promoting nutrient… Expand
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The Genus Spirillum: a Taxonomic Study1
The morphological, physiological, and nutritional characteristics and the deoxyribonucleic acid (DNA) base compositions of 39 strains of Spirillum (including the available type strains) were… Expand
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Cirrhosis, bile acids and gut microbiota
A picture is now starting to emerge regarding the liver-bile acid-microbiome axis. Increasing levels of the primary bile acid cholic acid (CA) causes a dramatic shift toward the Firmicutes,… Expand
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Modulation of the fecal bile acid profile by gut microbiota in cirrhosis.
BACKGROUND & AIMS The 7α-dehydroxylation of primary bile acids (BAs), chenodeoxycholic (CDCA) and cholic acid (CA) into the secondary BAs, lithocholic (LCA) and deoxycholic acid (DCA), is a key… Expand
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