HMGCR gene

Known as: hydroxymethylglutaryl-CoA reductase, HMG-CoA REDUCTASE, 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene 
This gene plays a role in the biosynthesis of steroids.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND Pharmacologic inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) are being evaluated in clinical… (More)
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2016
2016
OBJECTIVE To elucidate the common and distinct clinical features of immune-mediated necrotising myopathy (IMNM), also known as… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Considerable uncertainty exists as to whether lowering low-density lipoprotein cholesterol (LDL-C) by inhibiting the… (More)
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2015
2015
Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health issue with a prevalence of 15-30% in Western populations… (More)
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Highly Cited
2014
Highly Cited
2014
Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little… (More)
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE In addition to inducing a self-limited myopathy, statin use is associated with an immune-mediated necrotizing myopathy… (More)
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2010
2010
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme in the biosynthesis of cholesterol. We have… (More)
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2010
2010
OBJECTIVE Although statins are efficacious for lowering low-density lipoprotein cholesterol, there is wide interindividual… (More)
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Highly Cited
2008
Highly Cited
2008
UNLABELLED Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes… (More)
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2007
2007
The insulin signaling pathway has been implicated in several physiological and developmental processes. In mammals, it controls… (More)
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