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HMGCR gene

Known as: hydroxymethylglutaryl-CoA reductase, HMG-CoA REDUCTASE, 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene 
This gene plays a role in the biosynthesis of steroids.
National Institutes of Health

Related topics

Related topics

6 relations
3-hydroxy-3-methylglutaryl coenzyme A reductase activityHMGCR protein, humanHydroxymethylglutaryl coenzyme A reductaseHydroxymethylglutaryl-CoA reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Significant association of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) rs3846662 and sirtuin 1 (SIRT1) rs7895833 and apolipoprotein E (APOE) hypermethylation with mild cognitive impairment (MCI)
Supplemental Digital Content is available in the text 
2018
2018
Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed
Abstract The therapeutic approach with statins is widely used in the control of dyslipidemias. However, there is no laboratory… 
2018
2018
Statin resistance in Candida glabrata
Reduced efficacy of statins has been observed in people but the mechanism of this resistance is unclear and no statin-resistance… 
2017
2017
Down-regulation of single-stranded DNA-binding protein 1 expression induced by HCMV infection promotes lipid accumulation in cells
The objective of this study was to observe the infection of human cytomegalovirus (HCMV) to human umbilical vein endothelial… 
2015
2015
Reply: Genetic Variation in NPC1L1 and Risk of Gallstone Disease.
2014
2014
Possible sur-risque de survenue de cancers synchrones au cours des myosites nécrosantes auto-immunes à anti-HMGCR
2010
2010
The Effect of a Mutation in the 3-UTR Region of the HMGCR Gene on Cholesterol in Beijing-You Chickens
The 3-hydroxyl-3-methylglutaryl Coenzyme A reductase (HMGCR) gene was examined for polymorphisms in Beijing-you chickens. A “T… 
2010
2010
Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese.
BACKGROUND The association between single nucleotide polymorphisms (SNPs) at 3-hydroxy-3-methylglutaryl-coenzyme A reductase… 
2010
2010
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European…
The objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3… 
1994
1994
Cellular expression of an HMGCR promoter‐CAT fusion gene in transgenic mouse brain: Evidence for a developmental regulation in oligodendrocytes
The HMGCR gene encodes the 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase, which is the key enzyme for cholesterol synthesis… 
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