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Hydroxymethylglutaryl-CoA reductase
Known as:
Hydroxymethylglutaryl coenzyme A reductases
, 3 Hydroxy 3 methylglutaryl CoA Reductase
, hmg-coa reductase
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Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
National Institutes of Health
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Related topics
Related topics
13 relations
3-hydroxy-3-methylglutaryl coenzyme A reductase activity
3-hydroxy-3-methylglutaryl-coenzyme A
HMGCR gene
Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Broader (1)
Alcohol Oxidoreductases
Narrower (2)
HMGCR protein, human
Hydroxymethylglutaryl coenzyme A reductase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic…
J. Pfefferkorn
,
Chulho Choi
,
+16 authors
B. Tait
Journal of Medicinal Chemistry
2008
Corpus ID: 28261820
In light of accumulating evidence that aggressive LDL-lowering therapy may offer increased protection against coronary heart…
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Highly Cited
2006
Highly Cited
2006
Pleiotropic effects of statins and related pharmacological experimental approaches.
Marta Alegret
,
J. Silvestre
Timely topics in medicine. Cardiovascular…
2006
Corpus ID: 29669248
Statins, the most widely prescribed cholesterol-lowering drugs, are considered to be first-line therapeutics for the prevention…
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Review
2002
Review
2002
Hydroxymethylglutaryl-Coenzyme A Reductase Inhibitors in Osteoporosis Management
James C. Coons
The Annals of Pharmacotherapy
2002
Corpus ID: 37518307
OBJECTIVE: To evaluate the use and potential benefit of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins…
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2002
2002
Inhibition Of Proliferation And Signalling Mechanisms In Human Lymphocytes By Fluvastatin
D. Hillyard
,
Angus JM Cameron
,
+4 authors
A. Jardine
Clinical and Experimental Pharmacology and…
2002
Corpus ID: 25570176
1. Inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase (statins) reduce serum cholesterol and have proven…
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Highly Cited
2001
Highly Cited
2001
Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C-reactive protein.
P. L. van Haelst
,
J. V. van Doormaal
,
J. May
,
R. Gans
,
H. Crijns
,
J. Tervaert
European journal of internal medicine
2001
Corpus ID: 44754051
Review
2000
Review
2000
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
S. L. Beaird
Journal of the American Pharmacists Association
2000
Corpus ID: 42031476
Highly Cited
1999
Highly Cited
1999
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes.
F. Lammert
,
D. Q. Wang
,
B. Paigen
,
M. Carey
Journal of Lipid Research
1999
Corpus ID: 26110540
There is no consensus whether hepatic lipid regulatory enzymes play primary or secondary roles in cholesterol cholelithiasis. We…
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Highly Cited
1979
Highly Cited
1979
Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
B. W. Philipp
,
D. Shapiro
Journal of Lipid Research
1979
Corpus ID: 29095158
A simple and rapid mixed-phase method for the quantitative assay of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and a…
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Highly Cited
1977
Highly Cited
1977
Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.
G. Schroepfer
,
E. Parish
,
H. W. Chen
,
A. Kandutsch
Journal of Biological Chemistry
1977
Corpus ID: 30654075
Highly Cited
1975
Highly Cited
1975
Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver.
W. Reed
,
D. Clinkenbeard
,
M. Lane
Journal of Biological Chemistry
1975
Corpus ID: 6773139
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