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Hydroxymethylglutaryl-CoA reductase

Known as: Hydroxymethylglutaryl coenzyme A reductases, 3 Hydroxy 3 methylglutaryl CoA Reductase, hmg-coa reductase 
Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
National Institutes of Health

Related topics

Related topics

13 relations
3-hydroxy-3-methylglutaryl coenzyme A reductase activity3-hydroxy-3-methylglutaryl-coenzyme AHMGCR geneHydroxymethylglutaryl-CoA Reductase Inhibitors

Broader (1)

Alcohol Oxidoreductases

Narrower (2)

HMGCR protein, humanHydroxymethylglutaryl coenzyme A reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic…
In light of accumulating evidence that aggressive LDL-lowering therapy may offer increased protection against coronary heart… 
Highly Cited
2006
Highly Cited
2006
Pleiotropic effects of statins and related pharmacological experimental approaches.
Statins, the most widely prescribed cholesterol-lowering drugs, are considered to be first-line therapeutics for the prevention… 
Review
2002
Review
2002
Hydroxymethylglutaryl-Coenzyme A Reductase Inhibitors in Osteoporosis Management
OBJECTIVE: To evaluate the use and potential benefit of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins… 
2002
2002
Inhibition Of Proliferation And Signalling Mechanisms In Human Lymphocytes By Fluvastatin
1. Inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase (statins) reduce serum cholesterol and have proven… 
Highly Cited
2001
Highly Cited
2001
Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C-reactive protein.
Review
2000
Review
2000
HMG-CoA reductase inhibitors: assessing differences in drug interactions and safety profiles.
Highly Cited
1999
Highly Cited
1999
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes.
There is no consensus whether hepatic lipid regulatory enzymes play primary or secondary roles in cholesterol cholelithiasis. We… 
Highly Cited
1979
Highly Cited
1979
Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
A simple and rapid mixed-phase method for the quantitative assay of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and a… 
Highly Cited
1977
Highly Cited
1977
Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.
Highly Cited
1975
Highly Cited
1975
Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver.
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