FAQ

Hydroxymethylglutaryl-CoA reductase

Known as: Hydroxymethylglutaryl coenzyme A reductases, 3 Hydroxy 3 methylglutaryl CoA Reductase, hmg-coa reductase 
Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.

Topic mentions per year

Topic mentions per year

1978-2016
012319782016

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Related topics

15 relations
3-hydroxy-3-methylglutaryl coenzyme A reductase activity3-hydroxy-3-methylglutaryl-coenzyme AHMGCR geneHydroxymethylglutaryl-CoA Reductase Inhibitors
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Broader (1)

Alcohol Oxidoreductases

Narrower (2)

HMGCR protein, humanHydroxymethylglutaryl coenzyme A reductase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Hydroxymethylglutaryl-CoA reductase
physiological aspects
3-hydroxy-3-methylglutaryl-coenzyme A
Hydroxymethylglutaryl-CoA Reductase Inhibitors
chemical synthesis
HMGCR gene

Papers overview

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2013
2013
Cooked rice prevents hyperlipidemia in hamsters fed a high-fat/cholesterol diet by the regulation of the expression of hepatic genes involved in lipid metabolism.
Rice has many health-beneficial components for ameliorating obesity, diabetes, and dyslipidemia. However, the effect of cooked… (More)
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2012
2012
Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial
BACKGROUND Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory… (More)
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2012
2012
Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA Reductase
BACKGROUND Cholesterol is mainly synthesised in liver and the rate-limiting step is the reduction of 3-hydroxy-3methylglutaryl… (More)
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2010
2010
The Arabidopsis thaliana FPP synthase isozymes have overlapping and specific functions in isoprenoid biosynthesis, and complete loss of FPP synthase activity causes early developmental arrest.
Farnesyl diphosphate (FPP) synthase (FPS) catalyses the synthesis of FPP, the major substrate used by cytosolic and mitochondrial… (More)
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2010
2010
[Adverse drug reactions of hydroxymethylglutaryl-CoA reductase inhibitors reported to agency for medicinal products and medical devices].
Hydroxymethylglutaryl-CoA reductase inhibitors (statins) are drugs used in the treatment of chronic diseases and frequently in… (More)
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2006
2006
Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction.
OBJECTIVES To characterize the relationship between hydroxymethylglutaryl-CoA reductase inhibitors (statins) and outcomes in… (More)
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2006
2006
Rab1 defines a novel pathway connecting the pre-Golgi intermediate compartment with the cell periphery.
The function of the pre-Golgi intermediate compartment (IC) and its relationship with the endoplasmic reticulum (ER) and Golgi… (More)
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1986
1986
Hydroxymethylglutaryl-CoA reductase, a key enzyme in phytosterol synthesis?
Hydroxymethylglutaryl-CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA), the precursor of the myriad of… (More)
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1986
1986
Saprophytic production of Clavine alkaloids and activity of Hydroxymethylglutaryl-CoA reductase
In submergedClaviceps cultures the activity of hydroxymethylglutaryl-CoA reductase preceded the increase of alkaloid production… (More)
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1978
1978
Stimulation of hydroxymethylglutaryl-CoA reductase activity after a single dose of the porphyrogenic chemical, allylisopropylacetamide.
Hydroxymethylglutaryl-CoA reductase activity in fasting rats was almost doubled 12 h following a single dose (400 mg/kg) of the… (More)
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