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3-hydroxy-3-methylglutaryl-coenzyme A

Known as: Hydroxymethylglutaryl-CoA, S-(hydrogen 3-hydroxy-3-methylpentanedioate) coenzyme A, HMG-CoA 
An intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Acyl Coenzyme A
Hydroxymethylglutaryl-CoA reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Pharmacological properties of NK-104 ((+)-monocalcium bis¿(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl++ +]-3,5… 
Review
1997
Review
1997
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion.
Important advances in our understanding of the regulation of hepatic apolipoprotein B secretion have been made in the past year… 
Highly Cited
1995
Highly Cited
1995
Molecular Dissection of the Role of the Membrane Domain in the Regulated Degradation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (*)
We have previously shown that the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase from hamster… 
Highly Cited
1988
Highly Cited
1988
Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase in Drosophila melanogaster synthesizes mevalonate for the… 
Highly Cited
1986
Highly Cited
1986
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.
We here report the isolation and nucleotide sequencing of a full-length 3.3-kilobase cDNA for the cytoplasmic form of 3-hydroxy-3… 
Highly Cited
1979
Highly Cited
1979
Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
A simple and rapid mixed-phase method for the quantitative assay of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and a… 
Highly Cited
1977
Highly Cited
1977
Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.
Incubation of leukocytes in buffer alone devoid of lipoproteins does not lead to the induction of 3-hydroxy-3-methylglutaryl… 
Highly Cited
1968
Highly Cited
1968
Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.
1. The activities of hydroxymethylglutaryl-CoA synthase and lyase in rat liver were found to be two- to 15-fold greater than… 
Highly Cited
1966
Highly Cited
1966
The effect of palmityl coenzyme A on glucose 6-phosphate dehydrogenase and other enzymes.
Highly Cited
1963
Highly Cited
1963
INHIBITION OF CITRATE-SYNTHASE BY PALMITYL-COENZYME A.
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