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3-hydroxy-3-methylglutaryl-coenzyme A
Known as:
Hydroxymethylglutaryl-CoA
, S-(hydrogen 3-hydroxy-3-methylpentanedioate) coenzyme A
, HMG-CoA
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An intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Acyl Coenzyme A
Hydroxymethylglutaryl-CoA reductase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
T. Aoki
,
H. Nishimura
,
+11 authors
Y. Saito
Arzneimittel-Forschung
1997
Corpus ID: 40299909
Pharmacological properties of NK-104 ((+)-monocalcium bis¿(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl++ +]-3,5…
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Review
1997
Review
1997
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and hepatic apolipoprotein B secretion.
Murray W. Huff
,
John R. Burnett
Current Opinion in Lipidology
1997
Corpus ID: 25935934
Important advances in our understanding of the regulation of hepatic apolipoprotein B secretion have been made in the past year…
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Highly Cited
1995
Highly Cited
1995
Molecular Dissection of the Role of the Membrane Domain in the Regulated Degradation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (*)
H. Kumagai
,
K. Chun
,
R. D. Simoni
Journal of Biological Chemistry
1995
Corpus ID: 2762994
We have previously shown that the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase from hamster…
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Highly Cited
1988
Highly Cited
1988
Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase
F. Gertler
,
C. Chiu
,
L. Richter-Mann
,
D. Chin
Molecular and Cellular Biology
1988
Corpus ID: 36242953
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase in Drosophila melanogaster synthesizes mevalonate for the…
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Highly Cited
1986
Highly Cited
1986
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.
G. Gil
,
J. Goldstein
,
C. Slaughter
,
M. Brown
Journal of Biological Chemistry
1986
Corpus ID: 27615142
We here report the isolation and nucleotide sequencing of a full-length 3.3-kilobase cDNA for the cytoplasmic form of 3-hydroxy-3…
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Highly Cited
1979
Highly Cited
1979
Improved methods for the assay and activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
B. W. Philipp
,
D. Shapiro
Journal of Lipid Research
1979
Corpus ID: 29095158
A simple and rapid mixed-phase method for the quantitative assay of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and a…
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Highly Cited
1977
Highly Cited
1977
Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.
A. Fogelman
,
J. Seager
,
P. Edwards
,
G. Popják
Journal of Biological Chemistry
1977
Corpus ID: 32397722
Incubation of leukocytes in buffer alone devoid of lipoproteins does not lead to the induction of 3-hydroxy-3-methylglutaryl…
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Highly Cited
1968
Highly Cited
1968
Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.
D. Williamson
,
M. Bates
,
H. Krebs
Biochemical Journal
1968
Corpus ID: 6056537
1. The activities of hydroxymethylglutaryl-CoA synthase and lyase in rat liver were found to be two- to 15-fold greater than…
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Highly Cited
1966
Highly Cited
1966
The effect of palmityl coenzyme A on glucose 6-phosphate dehydrogenase and other enzymes.
K. Taketa
,
B. Pogell
Journal of Biological Chemistry
1966
Corpus ID: 29661136
Highly Cited
1963
Highly Cited
1963
INHIBITION OF CITRATE-SYNTHASE BY PALMITYL-COENZYME A.
O. Wieland
,
L. Weiss
Biochemical and Biophysical Research…
1963
Corpus ID: 38998334
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