3-hydroxy-3-methylglutaryl-coenzyme A

Known as: Hydroxymethylglutaryl-CoA, S-(hydrogen 3-hydroxy-3-methylpentanedioate) coenzyme A, HMG-CoA 
An intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from… (More)
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Angiogenesis is implicated in the pathogenesis of cancer, rheumatoid arthritis, and atherosclerosis and in the treatment of… (More)
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Review
2001
Review
2001
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or statins are potent inhibitors of cholesterol biosynthesis… (More)
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Highly Cited
1999
Highly Cited
1999
We resolved from spinach (Spinacia oleracea) leaf extracts four Ca2+-independent protein kinase activities that phosphorylate the… (More)
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Highly Cited
1998
Highly Cited
1998
The treatment of ischemic strokes is limited to prophylactic agents that block the coagulation cascade. Here, we show that… (More)
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Highly Cited
1998
Highly Cited
1998
Recent evidence suggests that apoptosis may be involved in the control of vascular smooth muscle cell (VSMC) number in… (More)
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Highly Cited
1995
Highly Cited
1995
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the irreversible conversion of 3-hydroxy-3-methylglutaryl… (More)
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Highly Cited
1993
Highly Cited
1993
Tocotrienols are natural farnesylated analogues of tocopherols which decrease hepatic cholesterol production and reduce plasma… (More)
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Highly Cited
1980
Highly Cited
1980
Compactin (ML-236B) and the related compound, mevinolin, are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A… (More)
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Highly Cited
1973
Highly Cited
1973
The activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34), the rate-limiting enzyme of hepatic cholesterol… (More)
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Highly Cited
1973
Highly Cited
1973
The homozygous form of the autosomal dominant disorder, familial hypercholesterolemia, is characterized by the presence in… (More)
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