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3-hydroxy-3-methylglutaryl-coenzyme A

Known as: Hydroxymethylglutaryl-CoA, S-(hydrogen 3-hydroxy-3-methylpentanedioate) coenzyme A, HMG-CoA 
An intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Acyl Coenzyme A
Hydroxymethylglutaryl-CoA reductase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Immune modulatory effects of statins
Despite major advances in recent years, immunosuppressive regimens for multiple sclerosis, rheumatoid arthritis, systemic lupus… Expand
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Highly Cited
2011
Highly Cited
2011
Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy.
OBJECTIVE In addition to inducing a self-limited myopathy, statin use is associated with an immune-mediated necrotizing myopathy… Expand
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Review
2004
Review
2004
The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
SummaryThe enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate, a… Expand
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Review
2001
Review
2001
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or statins are potent inhibitors of cholesterol biosynthesis… Expand
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Highly Cited
1998
Highly Cited
1998
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.
BACKGROUND Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in part by decreasing the availability of… Expand
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Highly Cited
1995
Highly Cited
1995
Is the Reaction Catalyzed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase a Rate-Limiting Step for Isoprenoid Biosynthesis in Plants?
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the irreversible conversion of 3-hydroxy-3-methylglutaryl… Expand
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Highly Cited
1993
Highly Cited
1993
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Tocotrienols are natural farnesylated analogues of tocopherols which decrease hepatic cholesterol production and reduce plasma… Expand
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Highly Cited
1980
Highly Cited
1980
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The structure and absolute configuration of… Expand
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Highly Cited
1978
Highly Cited
1978
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.
The two compounds compactin and ML-236B are identical fungal metabolites isolated from strains of Penicilliunz brevicompactum and… Expand
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Highly Cited
1973
Highly Cited
1973
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.
The activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34), the rate-limiting enzyme of hepatic cholesterol… Expand
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