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3-hydroxy-3-methylglutaryl-coenzyme A

Known as: Hydroxymethylglutaryl-CoA, S-(hydrogen 3-hydroxy-3-methylpentanedioate) coenzyme A, HMG-CoA 
An intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Despite major advances in recent years, immunosuppressive regimens for multiple sclerosis, rheumatoid arthritis, systemic lupus… Expand
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE In addition to inducing a self-limited myopathy, statin use is associated with an immune-mediated necrotizing myopathy… Expand
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Review
2004
Review
2004
SummaryThe enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate, a… Expand
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Review
2001
Review
2001
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or statins are potent inhibitors of cholesterol biosynthesis… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in part by decreasing the availability of… Expand
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Highly Cited
1995
Highly Cited
1995
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the irreversible conversion of 3-hydroxy-3-methylglutaryl… Expand
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Highly Cited
1993
Highly Cited
1993
Tocotrienols are natural farnesylated analogues of tocopherols which decrease hepatic cholesterol production and reduce plasma… Expand
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Highly Cited
1980
Highly Cited
1980
Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The structure and absolute configuration of… Expand
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Highly Cited
1978
Highly Cited
1978
The two compounds compactin and ML-236B are identical fungal metabolites isolated from strains of Penicilliunz brevicompactum and… Expand
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Highly Cited
1973
Highly Cited
1973
The activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34), the rate-limiting enzyme of hepatic cholesterol… Expand
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