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3-hydroxy-3-methylglutaryl-coenzyme A

Known as: Hydroxymethylglutaryl-CoA, S-(hydrogen 3-hydroxy-3-methylpentanedioate) coenzyme A, HMG-CoA 
An intermediate for the synthesis of mevalonic acid, ketone bodies and cholesterol and a metabolic product for leucine; it can be formed de novo from… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Acyl Coenzyme A
Hydroxymethylglutaryl-CoA reductase

Papers overview

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1993
1993
Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase expressed in Escherichia coli: production of homogeneous protein.
When overexpressed in Escherichia coli, the catalytic domain of Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase… 
1984
1984
In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone.
It has been previously demonstrated that the enzymic activity of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG… 
1983
1983
Isoprene synthesis in isolated embryonic Drosophila cells. II. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.
We used an established Drosophila cell line (Kc cells), which neither synthesized nor required cholesterol for growth, to… 
1980
1980
Regulation of hamster adrenal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.
In the adrenal gland of the hamster, the activity of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase [mevalonate:NADP… 
1979
1979
Relationship between activity of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase and secretion of very-low-density-lipoprotein cholesterol by the isolated perfused liver and in the intact rat…
The hepatic output of triacylglycerol and cholesterol from very-low-density lipoprotein (VLD lipoprotein), and the activity of 3… 
Highly Cited
1978
Highly Cited
1978
Regulation by plasma lipoproteins of progesterone biosynthesis and 3-hydroxy-3-methyl glutaryl coenzyme a reductase activity in cultured human choriocarcinoma cells.
The regulation of both the activity of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) reductase [mevalonate-NADP… 
Highly Cited
1977
Highly Cited
1977
Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.
Incubation of leukocytes in buffer alone devoid of lipoproteins does not lead to the induction of 3-hydroxy-3-methylglutaryl… 
Highly Cited
1977
Highly Cited
1977
Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities.
Short- and long-term effects of ethanol on HMG-CoA reductase (EC 1.1.1.34) and cholesterol 7alpha-hydroxylase activities in rat… 
1977
1977
Persistence of dietary suppression of 3-hydroxy-3-methylglutaryl coenzyme-A reductase during development in rats.
Rat pups suckled by dams fed either a semipurified diet or a commercial rat feed displayed an increase in hepatic 3-hydroxy-3… 
Highly Cited
1973
Highly Cited
1973
Regulatory effects of dietary sterols and bile acids on rat intestinal HMG CoA reductase.
The specific activity (concentration) of microsomal HMG CoA reductase of intestinal crypt cells was studied in rats fed sterols…