The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver.
The bearing of these findings on various problems, including the number of NAD(+)-NADH pools in liver cells; the applicability of the method to tissues other than liver; the transhydrogenase activity of glutamate dehydrogenase; the physiological significance of the difference of the redox states of mitochondria and cytoplasm; aspects of the regulation of theredox state of cell compartments; the steady-state concentration of mitochondrial oxaloacetate.
Cytosolic phosphorylation potential.
The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver.
The application of the method of calculation to data published by Kraupp, Adler-Kastner, Niessner & Plank (1967), Goldberg, Passonneau & Lowry (1966) and Kauffman, Brown,passonneau and Lowry (1968) shows that the redox states of the NAD and NADP couples in cardiac-muscle cytoplasm and in mouse-brain cytop lasm are of the same order as those in rat liver.
The Making of a Scientist
- H. Krebs
This address by Sir Hans Krebs at the inauguration of the Department of Biochemistry at the University of Newcastle upon Tyne earlier this year argued for the perpetuation of centres of excellence.
Studies on the mechanism of the antifungal action of benzoate.
There is a relationship between intracellular pH, phosphofructokinase inhibition and CO2 production, suggesting that the antifungal action of Benzoate is caused by an accumulation of benzoate at low external pH, which lowers the intrace cellular pH into the range where phosphofructureokinase is sensitive.
Ketone-body utilization by adult and suckling rat brain in vivo.
The results indicate that ketone bodies are major metabolic fuels of the brain of the suckling rat under normal conditions and are independent of the nutritional state.
Regulation of the pentose phosphate cycle.
The hypothesis that GSSG exerts a fine control of the pentose phosphate cycle by counteracting the NADPH inhibition of glucose 6-phosphate dehydrogenase is discussed.
Metabolism of amino-acids: The synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues.
- H. Krebs
- Biology, ChemistryBiochemical Journal
- 1 August 1935
This investigation found that glutamic acid behaves differently from all the other ax-amino-acids in guinea-pig and rabbit kidneys, in that, although it increases the oxygen uptake even more than any other amino-acid of the i-series, in most cases it actually diminishes ammonia formation.
[The regulation of metabolism].
- H. Krebs
- Biology, MedicineDeutsche Medizinische Wochenschrift
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