Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
- T. Aoki, H. Nishimura, Y. Saito
- Chemistry, BiologyArzneimittel-Forschung
- 1 August 1997
Results indicate that NK-104 is a potent, liver-selective, long-acting HMG-CoA reductase inhibitor with a high cholesterol- and triglyceride-lowering potency.
Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell.
- T. Maejima, H. Yamazaki, Y. Saito
- Biology, ChemistryBiochemical and Biophysical Research…
- 12 November 2004
NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery.
- M. Kitahara, T. Kanaki, Y. Saito
- Biology, MedicineJapanese Journal of Pharmacology
- 1998
It is suggested that NK-104 suppresses balloon-injury-induced neointimal thickening through inhibition of intimal smooth muscle cell growth and extracellular matrix accumulation.
Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1
- K. Yamanaka, Y. Urano, W. Takabe, Y. Saito, N. Noguchi
- Biology, ChemistryCell Death and Disease
- 1 January 2014
It is suggested that it is ACAT1-catalyzed 24S-OHC esterification and the resulting lipid droplet formation that is the initial key event which is induced being determined by caspase activity.
Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells.
- S. Morikawa, M. Umetani, Y. Saito
- Biology, ChemistryJournal of atherosclerosis and thrombosis
- 2000
NK-104 is most effective in inducing LDL receptor mRNA in Hep G2 cells when cells were treated with a 200-fold excess of the IC50 concentration of each inhibitor, indicating that the effect of HMG-CoA reduct enzyme inhibitors on the upregulation of mRNA for reductase and LDL receptor are different from each other and among these lipophilic inhibitors.
An evaluation of the effects of cytokines on intracellular oxidative production in normal neutrophils by flow cytometry.
- L. Yuan, S. Inoue, Y. Saito, O. Nakajima
- BiologyExperimental Cell Research
- 1 December 1993
It is indicated that some kinds of cytokines enhance oxidative production and cause morphological changes in neutrophils and the most prominently effective cytokine, GM-CSF, initially caused enlargement of cell size and irregularity of the cell surface and subsequently increased H2O2 production by neutrophil.
Identification of cembratriene-4,6-diol as antitumor-promoting agent from cigarette smoke condensate.
- Y. Saito, H. Takizawa, S. Konishi, D. Yoshida, S. Mizusaki
- Biology, ChemistryCarcinogenesis
- 1 August 1985
The present data suggest that EBV-EA inhibition assay using Raji cells is effective for the first screening of inhibitors of tumor promotion, and provide evidence that CSC contains antitumor- Promoting agents in addition to carcinogenic and tumor-promoting agents already reported.
Mechanism of the lipid-lowering effect of ethyl all-cis-5,8,11,14,17-icosapentaenoate.
- K. Mizuguchi, T. Yano, Y. Saito
- Biology, ChemistryEuropean Journal of Pharmacology
- 26 January 1993
Antimutagenic effects of dehydrozingerone and its analogs on UV-induced mutagenesis in Escherichia coli.
- N. Motohashi, Y. Ashihara, C. Yamagami, Y. Saito
- Chemistry, BiologyMutation research
- 9 June 1997
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