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The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver.
TLDR
The bearing of these findings on various problems, including the number of NAD(+)-NADH pools in liver cells; the applicability of the method to tissues other than liver; the transhydrogenase activity of glutamate dehydrogenase; the physiological significance of the difference of the redox states of mitochondria and cytoplasm; aspects of the regulation of theredox state of cell compartments; the steady-state concentration of mitochondrial oxaloacetate.
Ketone-body utilization by adult and suckling rat brain in vivo.
TLDR
The results indicate that ketone bodies are major metabolic fuels of the brain of the suckling rat under normal conditions and are independent of the nutritional state.
Severe hypoglycemia and hyperinsulinemia in falciparum malaria.
TLDR
Observations indicate that in falciparum malaria quinine-induced insulin secretion may precipitate hypoglycemia, but other factors, including the large glucose requirements of the malaria parasites may also contribute.
Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues.
TLDR
It is concluded that the activities of the relevant enzymes in the adult rat do not control the variations in the rate of ketone-body utilization that occur in starvation or alloxan-diabetes.
HYPOGLYCAEMIA IN AFRICAN CHILDREN WITH SEVERE MALARIA
Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.
TLDR
It is concluded that variations in the concentrations of enzymes involved in acetoacetate synthesis play no major role in the regulation of ketone-body formation in starvation and alloxan-diabetes.
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