Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
IMPORTANCE Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established… (More)
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Highly Cited
2007
Highly Cited
2007
Spironolactone is recommended as fourth-line therapy for essential hypertension despite few supporting data for this indication… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Aldosterone has been suggested to play a role in the initiation and progression of diabetic nephropathy. Currently… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with… (More)
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Highly Cited
2002
Highly Cited
2002
Angiotensin II plays an important role in vascular remodeling. We investigated the role of aldosterone, which is stimulated by… (More)
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Highly Cited
2000
Highly Cited
2000
Highly Cited
2000
BACKGROUND The RALES study showed that spironolactone, added to conventional therapy for chronic heart failure, dramatically… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… (More)
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