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Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (22)

7-propyl spirolactoneAldactoneFlumachPracton
AmilorideAnuriaCongestive heart failureHypertensive disease

Broader (4)

DiureticsMineralocorticoid Receptor AntagonistsPregnenessteroid spirolactone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Prognostic Importance of Impaired Systolic Function in Heart Failure With Preserved Ejection Fraction and the Impact of Spironolactone
Background— Impairment in left ventricular systolic function has been described in heart failure (HF) with preserved ejection… 
Highly Cited
2006
Highly Cited
2006
Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease.
Experimental evidence suggests that aldosterone contributes to progressive kidney disease. Angiotensin-converting enzyme… 
Review
2006
Review
2006
Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research.
Highly Cited
2006
Highly Cited
2006
Spironolactone in type 2 diabetic nephropathy: effects on proteinuria, blood pressure and renal function
Objective To study the effects of addition of spironolactone to angiotensin-converting enzyme (ACE) inhibition or angiotensin II… 
Highly Cited
2005
Highly Cited
2005
Beneficial impact of spironolactone in diabetic nephropathy.
BACKGROUND Aldosterone has been suggested to play a role in the initiation and progression of diabetic nephropathy. Currently… 
Review
2004
Review
2004
Pharmacological profile of progestins.
Highly Cited
2004
Highly Cited
2004
Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.
BACKGROUND Glomerular and tubulointerstitial injury leads to chronic impairment of renal function, and thus, reversal of the… 
Highly Cited
2003
Highly Cited
2003
Effects of Experience on Fetal Voice Recognition
The ability of human fetuses to recognize their own mother's voice was examined. Sixty term fetuses were assigned to one of two… 
Highly Cited
1986
Highly Cited
1986
Basilar membrane mechanics at the base of the chinchilla cochlea. I. Input-output functions, tuning curves, and response phases.
Basilar membrane (BM) velocity was measured at a site 3.5 mm from the basal end of the chinchilla cochlea using the Mössbauer… 
Highly Cited
1981
Highly Cited
1981
Diuretic-induced ventricular ectopic activity.
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