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Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (22)

7-propyl spirolactoneAldactoneFlumachPracton
AmilorideAnuriaCongestive heart failureHypertensive disease

Broader (4)

DiureticsMineralocorticoid Receptor AntagonistsPregnenessteroid spirolactone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
International variations in the treatment and co‐morbidity of left ventricular systolic dysfunction: Data from the EuroHeart Failure Survey
Highly Cited
2005
Highly Cited
2005
Low-resistance multi-walled carbon nanotube vias with parallel channel conduction of inner shells [IC interconnect applications]
We have succeeded in lowering the resistance of multi-walled carbon nanotube (MWNT) vias, using parallel channel conduction of… 
Highly Cited
1998
Highly Cited
1998
Electron beam and scanning probe lithography: A comparison
Electron beam lithography (EBL) and scanning probe lithography (SPL) are electron exposure techniques capable of high resolution… 
Review
1985
Review
1985
Hirsutism: evaluation and treatment.
Highly Cited
1983
Highly Cited
1983
Negative effects of diuretic drugs on metabolic risk factors for coronary heart disease: possible alternative drug therapies.
Highly Cited
1982
Highly Cited
1982
Patterns of hair cell loss in chick basilar papilla after intense auditory stimulation. Exposure duration and survival time.
Ten-day-old chicks were exposed to a pure tone (1.5 kHz) or white noise at 125 dB SPL avg. RMS for 4 to 24 hours, and were… 
Highly Cited
1976
Highly Cited
1976
Corticoid receptors in rat brain: evidence for an aldosterone receptor.
The existence of high and low affinity mineralocorticoid-binding macromolecules (receptors) has been demonstrated in vitro in… 
Highly Cited
1974
Highly Cited
1974
Noise‐induced inner ear damage in newborn and adult guinea pigs
Two‐day (Group A), eight‐day (Group B), and eight‐month (Group C) old guinea pigs were exposed to 30 continuous hours of white… 
Highly Cited
1973
Highly Cited
1973
Specific cytoplasmic glucocorticoid hormone receptors in lactating mammary glands.
Specific binding of dexamethasone-t by the cyto- plasmic fraction of mouse lactating mammary glands was studied. The specific… 
Highly Cited
1972
Highly Cited
1972
Total-body potassium in hypertension patients during prolonged diuretic therapy.
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