Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… (More)
National Institutes of Health

Related topics

Related topics

41 relations

Narrower (21)

AldactoneFlumachPractonRU 28318
(More)
AmilorideAnuriaCongestive heart failureHypertensive disease
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Broader (3)

DiureticsMineralocorticoid Receptor AntagonistsPregnenes

Papers overview

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Highly Cited
2013
Highly Cited
2013
Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.
IMPORTANCE Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established… (More)
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Highly Cited
2007
Highly Cited
2007
Effect of spironolactone on blood pressure in subjects with resistant hypertension.
Spironolactone is recommended as fourth-line therapy for essential hypertension despite few supporting data for this indication… (More)
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Highly Cited
2005
Highly Cited
2005
Beneficial impact of spironolactone in diabetic nephropathy.
BACKGROUND Aldosterone has been suggested to play a role in the initiation and progression of diabetic nephropathy. Currently… (More)
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Highly Cited
2004
Highly Cited
2004
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.
BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation… (More)
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Highly Cited
2003
Highly Cited
2003
Efficacy of low-dose spironolactone in subjects with resistant hypertension.
BACKGROUND Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with… (More)
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Highly Cited
2002
Highly Cited
2002
Spironolactone improves angiotensin-induced vascular changes and oxidative stress.
Angiotensin II plays an important role in vascular remodeling. We investigated the role of aldosterone, which is stimulated by… (More)
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Highly Cited
2000
Highly Cited
2000
Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone…
BACKGROUND In congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has… (More)
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Highly Cited
2000
Highly Cited
2000
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
 
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Highly Cited
2000
Highly Cited
2000
Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure…
BACKGROUND The RALES study showed that spironolactone, added to conventional therapy for chronic heart failure, dramatically… (More)
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Highly Cited
1999
Highly Cited
1999
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… (More)
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