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Spironolactone
Known as:
Spironolactone [Chemical/Ingredient]
, Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-
, Spironolattone
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A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory…
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National Institutes of Health
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Related topics
Related topics
43 relations
Narrower (22)
7-propyl spirolactone
Aldactone
Flumach
Practon
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Amiloride
Anuria
Congestive heart failure
Hypertensive disease
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Broader (4)
Diuretics
Mineralocorticoid Receptor Antagonists
Pregnenes
steroid spirolactone
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Spironolactone for heart failure with preserved ejection fraction.
B. Pitt
,
M. Pfeffer
,
+20 authors
S. Mckinlay
New England Journal of Medicine
2014
Corpus ID: 23481955
BACKGROUND Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left…
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Review
2009
Review
2009
Synthesis and applications of Rhodamine derivatives as fluorescent probes.
Mariana Beija
,
C. Afonso
,
J. Martinho
Chemical Society Reviews
2009
Corpus ID: 1444897
Rhodamine dyes are widely used as fluorescent probes owing to their high absorption coefficient and broad fluorescence in the…
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Highly Cited
2007
Highly Cited
2007
Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension
N. Chapman
,
J. Dobson
,
+4 authors
N. Poulter
HYPERTENSION
2007
Corpus ID: 7997513
Spironolactone is recommended as fourth-line therapy for essential hypertension despite few supporting data for this indication…
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Highly Cited
2004
Highly Cited
2004
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.
M. Bristow
,
L. Saxon
,
+9 authors
A. Feldman
New England Journal of Medicine
2004
Corpus ID: 35704614
BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation…
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Highly Cited
2004
Highly Cited
2004
Robust image segmentation using FCM with spatial constraints based on new kernel-induced distance measure
Songcan Chen
,
Daoqiang Zhang
IEEE Transactions on Systems, Man, and…
2004
Corpus ID: 1315927
Fuzzy c-means clustering (FCM) with spatial constraints (FCM/spl I.bar/S) is an effective algorithm suitable for image…
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Highly Cited
2003
Highly Cited
2003
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial
J. McMurray
,
J. Östergren
,
+6 authors
M. Pfeffer
The Lancet
2003
Corpus ID: 7383954
Highly Cited
2002
Highly Cited
2002
Spironolactone Improves Angiotensin-Induced Vascular Changes and Oxidative Stress
A. Virdis
,
M. Neves
,
F. Amiri
,
Emilie C. Viel
,
R. Touyz
,
E. Schiffrin
HYPERTENSION
2002
Corpus ID: 13173611
Abstract—Angiotensin II plays an important role in vascular remodeling. We investigated the role of aldosterone, which is…
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Highly Cited
2000
Highly Cited
2000
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
B. Pitt
,
F. Zannad
,
+5 authors
J. Wittes
2000
Corpus ID: 76371899
Highly Cited
2000
Highly Cited
2000
Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure: Insights From the Randomized Aldactone…
F. Zannad
,
F. Alla
,
B. Dousset
,
A. Perez
,
B. Pitt
Circulation
2000
Corpus ID: 2575979
BackgroundIn congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has…
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Highly Cited
1999
Highly Cited
1999
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
B. Pitt
,
F. Zannad
,
+5 authors
J. Wittes
New England Journal of Medicine
1999
Corpus ID: 45060523
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663…
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