Skip to search formSkip to main contentSkip to account menu
You are currently offline. Some features of the site may not work correctly.

Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Summary Background Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • table 3
Highly Cited
2014
Highly Cited
2014
BACKGROUND Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left… Expand
  • table 1
  • table 1
  • table 2
  • figure 1
  • figure 2
Highly Cited
2013
Highly Cited
2013
IMPORTANCE Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Highly Cited
2007
Highly Cited
2007
Spironolactone is recommended as fourth-line therapy for essential hypertension despite few supporting data for this indication… Expand
  • table 1
  • figure 1
  • table 2
  • figure 2
  • table 3
Highly Cited
2004
Highly Cited
2004
BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation… Expand
  • table 1
  • figure 1
  • table 2
  • figure 3
Highly Cited
2004
Highly Cited
2004
Fuzzy c-means clustering (FCM) with spatial constraints (FCM/spl I.bar/S) is an effective algorithm suitable for image… Expand
  • table 1
  • table 3
Highly Cited
2003
Highly Cited
2003
BACKGROUND Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with… Expand
Highly Cited
2000
Highly Cited
2000
BackgroundIn congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 5
Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… Expand
  • figure 1
  • figure 2
  • table 4