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Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left… 
Review
2009
Review
2009
Rhodamine dyes are widely used as fluorescent probes owing to their high absorption coefficient and broad fluorescence in the… 
Highly Cited
2007
Highly Cited
2007
Spironolactone is recommended as fourth-line therapy for essential hypertension despite few supporting data for this indication… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation… 
Highly Cited
2004
Highly Cited
2004
Fuzzy c-means clustering (FCM) with spatial constraints (FCM/spl I.bar/S) is an effective algorithm suitable for image… 
Highly Cited
2002
Highly Cited
2002
Abstract—Angiotensin II plays an important role in vascular remodeling. We investigated the role of aldosterone, which is… 
Highly Cited
2000
Highly Cited
2000
BackgroundIn congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has… 
Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663…