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Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… Expand
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (22)

7-propyl spirolactoneAldactoneFlumachPracton
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AmilorideAnuriaCongestive heart failureHypertensive disease
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Broader (4)

DiureticsMineralocorticoid Receptor AntagonistsPregnenessteroid spirolactone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
Summary Background Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses… Expand
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Highly Cited
2014
Highly Cited
2014
Spironolactone for heart failure with preserved ejection fraction.
BACKGROUND Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left… Expand
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Highly Cited
2013
Highly Cited
2013
Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial.
IMPORTANCE Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established… Expand
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Highly Cited
2007
Highly Cited
2007
Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension
Spironolactone is recommended as fourth-line therapy for essential hypertension despite few supporting data for this indication… Expand
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Highly Cited
2004
Highly Cited
2004
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.
BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation… Expand
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Highly Cited
2004
Highly Cited
2004
Robust image segmentation using FCM with spatial constraints based on new kernel-induced distance measure
Fuzzy c-means clustering (FCM) with spatial constraints (FCM/spl I.bar/S) is an effective algorithm suitable for image… Expand
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Highly Cited
2003
Highly Cited
2003
Efficacy of low-dose spironolactone in subjects with resistant hypertension.
BACKGROUND Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with… Expand
Highly Cited
2000
Highly Cited
2000
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Highly Cited
2000
Highly Cited
2000
Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure: Insights From the Randomized Aldactone…
BackgroundIn congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has… Expand
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Highly Cited
1999
Highly Cited
1999
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
BACKGROUND AND METHODS Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663… Expand
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