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Spironolactone

Known as: Spironolactone [Chemical/Ingredient], Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, Spironolattone 
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (22)

7-propyl spirolactoneAldactoneFlumachPracton
AmilorideAnuriaCongestive heart failureHypertensive disease

Broader (4)

DiureticsMineralocorticoid Receptor AntagonistsPregnenessteroid spirolactone

Papers overview

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2004
2004
On the stability of the pulsewidth-modulated C/spl acute/uk converter
It has been observed that a stabilizing controller for the state-space-average model of a pulsewidth-modulated (PWM) DC-DC… 
1998
1998
H/sub /spl infin// estimation for nonlinear systems
An output estimator for a nonlinear system (the extended H/spl infin/ estimator) is developed based on suboptimal H/spl infin… 
1986
1986
Loudness reduction and adaptation induced by a contralateral tone.
An intermittent tone in one ear may induce a large decline in the loudness of a continuous tone in the contralateral ear [Botte… 
1981
1981
A fault-tolerant 30 ns/375 mW 16Kx1 NMOS static RAM
A fault-tolerant 30950 mil/SUP 2/ (19.9 mm/SUP 2/) 16K/spl times/1 static MOS RAM has been fabricated with a single polysilicon E… 
1977
1977
Effect of spironolactone on urinary kallikrein excretion in patients with essential hypertension and in primary aldosteronism.
Urinary kallikrein excretion was measured before and after administration of spironolactone in 12 patients with essential… 
1974
1974
Reduced aldosterone secretion during spironolactone treatment in primary aldosteronism: report of a case.
ABSTRACT A 51-yr-old woman is presented with the typical clinical and biochemical picture of primary aldosteronism. During two… 
Highly Cited
1973
Highly Cited
1973
The effect of spironolactone on antipyrine metabolism in man.
Spironolactone treatment was associated with a decrease in the plasma antipyrine half-life in all 9 volunteers studied. This was… 
1972
1972
Regulation of middle ear sound transmission in the nonanesthetized rabbit.
The regulation of sound transmission through the middle ear of nonanesthetized rabbits was quantitatively investigated by… 
1969
1969
Prevention of indomethacin-induced intestinal ulcers by spironolactone and norbolethone.
Both spironolactone (an antimineralocorticoid compound) and norbolethone (an anabolic steroid) protect the rat against the… 
1962
1962
Steroidportein interactions. IX. Interaction of aldosterone with human serum proteins in competition with spirolactones and other steroids.
The effect of spirolactones (SC-9420 and SC-8109) on aldosterone binding to serum proteins was studied and compared with the…