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The investigation of linkage between a quantitative trait and a marker locus
Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-allele locus that governs a quantitative trait. Random mating and linkageExpand
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Spontaneous Neoplasm Incidences in Fischer 344 Rats and B6C3F1 Mice in Two-Year Carcinogenicity Studies: A National Toxicology Program Update
Spontaneous neoplasm rates were determined for control Fischer 344 (F344) rats and B6C3F, mice from 2-yr rodent carcinogenicity studies carried out by the National Toxicology Program (NTP). The mostExpand
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Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.
Four widely used in vitro assays for genetic toxicity were evaluated for their ability to predict the carcinogenicity of selected chemicals in rodents. These assays were mutagenesis in Salmonella andExpand
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Urolithiasis and bladder carcinogenicity of melamine in rodents.
Melamine (2,4,6-triamino-s-triazine) was administered in the diet to F344 rats or B6C3F1 mice for 13 weeks (subchronic) or for 103 weeks (chronic) to determine its toxicologic profile, includingExpand
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Structure and control of a cell-cell adhesion complex associated with spermiation in rat seminiferous epithelium.
Spermiation, the release of late spermatids from the Sertoli cell, is disrupted by a number of toxicants. Control of the spermiation process, and the proteins that interact to adhere matureExpand
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A reexamination of false-positive rates for carcinogenesis studies.
  • J. Haseman
  • Medicine
  • Fundamental and applied toxicology : official…
  • 1983
False-positive rates in the National Cancer Institute/National Toxicology Program (NCI/NTP) two-year carcinogenesis bioassay are examined. Previous studies that have reported high (20-50%)Expand
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Natural history of body weight gain, survival, and neoplasia in the F344 rat.
This study involved the fact that knowledge of the natural incidence of neoplastic lesions is essential for interpretation of experiments designed to reveal the effects of potential carcinogens.Expand
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Prediction of Rodent Carcinogenesis: An Evaluation of Prechronic Liver Lesions as Forecasters of Liver Tumors in NTP Carcinogenicity Studies
The National Toxicology Program (NTP) developed the chronic 2-year bioassay as a mechanism for predicting the carcinogenic potential of chemicals in humans. The cost and duration of these studies hasExpand
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Use of Historical Control Data in Carcinogenicity Studies in Rodents
This paper considers the use of historical control data in the evaluation of tumor incidences from carcinogenicity studies in rodents. Although the most appropriate control group for interpretativeExpand
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Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium.
Immunolocalization of transforming growth factor alpha (TGF-Alpha), epidermal growth factor (EGF), insulinlike growth factor (IGF)-I, vascular endothelial growth factor (VEGF(165,189,121)), basicExpand
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