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Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging
At present, there is an extensive body of literature documenting the participation of estrogen receptors (ER) and progesterone receptors (PR) in mammary gene expression. Yet, the precise roles ofExpand
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Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands.
In this report we document the creation of transgenic mice in which the native ratio of A and B forms of progesterone receptor (PR) has been altered by the introduction of additional A form asExpand
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Impact of progesterone receptor on cell-fate decisions during mammary gland development.
Mammary epithelium contains lineage-limited progenitors that give rise to cells that form distinct morphological structures, ducts vs. lobules, depending on the endocrine status of the female.Expand
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Roles of Estrogen and Progesterone in Normal Mammary Gland Development: Insights from Progesterone Receptor Null Mutant Mice and In Situ Localization of Receptor
  • G. Shyamala
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
  • 28 February 1997
In contrast to most other organs, the development of normal mammary glands occurs mostly in the postnatal state and in a discontinuous fashion. In all species, the glands are composed of various cellExpand
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Developmental regulation of murine mammary progesterone receptor gene expression.
Previously we have shown that in normal murine mammary glands progesterone receptor (PgR) levels are modulated as a function of development and differentiation such that lactating mammary glands doExpand
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Proliferation of Estrogen Receptor-α-Positive Mammary Epithelial Cells Is Restrained by Transforming Growth Factor-β1 in Adult Mice
Transforming growth factor (TGF)-β1 is a potent inhibitor of mammary epithelial proliferation. In human breast, estrogen receptor (ER)-α cells rarely co-localize with markers of proliferation, butExpand
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Estrogen receptors in the rat uterus. Studies on the interaction of cytosol and nuclear binding sites.
Abstract Studies on the interrelationship of binding sites for estrogens found in cytosol and nuclear fractions of the rat uterus show that 17β-estradiol is first associated with a protein (9 S)Expand
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Effect of oestradiol on progesterone receptors in normal mammary glands and its relationship with lactation.
Mammary glands of lactating mice, either intact or ovariectomized, do not contain detectable amounts of progesterone receptors and this lack of receptors persists also in tissues of animals treatedExpand
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Relative distribution of estrogen and progesterone receptors among the epithelial, adipose, and connective tissue components of the normal mammary gland.
The present studies were undertaken to determine the relative distribution of estrogen and progesterone receptors (PgR) in the epithelial, adipose, and connective tissues of normal mouse mammaryExpand
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Progesterone Signaling and Mammary Gland Morphogenesis
  • G. Shyamala
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • 6 August 1999
Progesterone was identified as a mammogenichormone several years ago but until now its precise rolein mammary development has remained obscure. Recentlywith the generation of several transgenic mouseExpand
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