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Mineralocorticoid Receptor Antagonists

Known as: Mineralocorticoid Antagonists, Receptor Antagonists, Mineralocorticoid, Aldosterone Receptor Antagonist 
A class of agents that act by selectively inhibiting aldosterone receptor activation with diuretic activity. Aldosterone receptor antagonists bind to… 
National Institutes of Health

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Narrower (7)

Aldosterone AntagonistsCanrenoic AcidCanrenoneRU 28318
In BloodMineralocorticoid Receptor Antagonists [MoA]aspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Factors associated with underuse of mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction: an analysis of 11 215 patients from the Swedish Heart Failure Registry
Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF), but are… 
Review
2016
Review
2016
Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis
BackgroundHypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment… 
Highly Cited
2016
Highly Cited
2016
Steroidal and Nonsteroidal Mineralocorticoid Receptor Antagonists Cause Differential Cardiac Gene Expression in Pressure Overload-induced Cardiac Hypertrophy
Abstract: Pharmacological blockade of mineralocorticoid receptors (MR) is known as an efficacious therapy in chronic heart… 
Review
2011
Review
2011
The 2011 Canadian Cardiovascular Society heart failure management guidelines update: focus on sleep apnea, renal dysfunction, mechanical circulatory support, and palliative care.
Highly Cited
2009
Highly Cited
2009
Extracellular Cardiac Matrix Biomarkers in Patients With Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction and Heart Failure: Insights From the Eplerenone Post–Acute Myocardial…
Background— Aldosterone stimulates cardiac collagen synthesis. Circulating biomarkers of collagen turnover provide a useful tool… 
Highly Cited
2006
Highly Cited
2006
Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease.
Experimental evidence suggests that aldosterone contributes to progressive kidney disease. Angiotensin-converting enzyme… 
Highly Cited
2006
Highly Cited
2006
Double-blind, placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting…
Studies have shown that dual therapy with angiotensin-converting enzyme inhibitors (ACEI) and either angiotensin II receptor… 
Highly Cited
2005
Highly Cited
2005
Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study.
BACKGROUND Experimental evidence suggests that aldosterone may contribute to progressive kidney disease. Although angiotensin… 
Highly Cited
2002
Highly Cited
2002
Mineralocorticoid Receptor Antagonism in Experimental Atherosclerosis
Background—Aldosterone has been implicated in the effects of angiotensin II in the vasculature. We hypothesized that there is… 
Highly Cited
2002
Highly Cited
2002
Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: results from the RALES neurohormonal substudy.
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