Mineralocorticoid Receptor Antagonists

Known as: Mineralocorticoid Antagonists, Receptor Antagonists, Mineralocorticoid, Aldosterone Receptor Antagonist 
A class of agents that act by selectively inhibiting aldosterone receptor activation with diuretic activity. Aldosterone receptor antagonists bind to… (More)
National Institutes of Health

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Aldosterone AntagonistsCanrenoic AcidCanrenoneRU 28318
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In BloodMineralocorticoid Receptor Antagonists [MoA]aspects of radiation effectschemical synthesis
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Papers overview

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2015
2015
Mineralocorticoid receptor antagonists modulate galectin-3 and interleukin-33/ST2 signaling in left ventricular systolic dysfunction after acute myocardial infarction.
OBJECTIVES This study aimed to evaluate the specific role of the 2 available mineralocorticoid receptor antagonists (MRAs… (More)
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Review
2013
Review
2013
Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine
Spironolactone was first developed over 50 years ago as a potent mineralocorticoid receptor (MR) antagonist with undesirable side… (More)
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Review
2012
Review
2012
Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice.
Mineralocorticoid receptor antagonists (MRAs) improve survival and reduce morbidity in patients with heart failure, reduced… (More)
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Review
2009
Review
2009
Aldosterone antagonists for preventing the progression of chronic kidney disease.
BACKGROUND Treatment with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) is increasingly… (More)
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Highly Cited
2007
Highly Cited
2007
Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism.
Exposure to excess aldosterone results in cardiac damage in hypertensive states. We evaluated the long-term cardiac structural… (More)
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Highly Cited
2006
Highly Cited
2006
Double-blind, placebo-controlled study on the effect of the aldosterone receptor antagonist spironolactone in patients who have persistent proteinuria and are on long-term angiotensin-converting…
Studies have shown that dual therapy with angiotensin-converting enzyme inhibitors (ACEI) and either angiotensin II receptor… (More)
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Highly Cited
2005
Highly Cited
2005
Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study.
BACKGROUND Experimental evidence suggests that aldosterone may contribute to progressive kidney disease. Although angiotensin… (More)
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Review
2005
Review
2005
Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension.
Hypertension in blacks is more prevalent and less often controlled than the hypertension of other ethnic groups. We sought to… (More)
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2004
2004
Mineralocorticoid receptor antagonists do not block rapid ERK activation by aldosterone.
Aldosterone can elicit rapid nongenomic effects both in vivo and in vitro, often mediated by signal transduction cascades… (More)
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Highly Cited
2002
Highly Cited
2002
Mineralocorticoid receptor antagonism in experimental atherosclerosis.
BACKGROUND Aldosterone has been implicated in the effects of angiotensin II in the vasculature. We hypothesized that there is… (More)
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