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Canrenone

Known as: Aldadiene, Canrenone [Chemical/Ingredient], Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone, (17alpha)- 
An aldosterone antagonist with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (3)

11614 R.P.Canrenoate PotassiumPhanurane
Canrenone:MCnc:Pt:Ser/Plas:QnCanrenone:MRat:24H:Urine:QnCanrenone:Mass:Pt:Dose:QnCanrenone:PrThr:Pt:Urine:Ord

Broader (1)

Mineralocorticoid Receptor Antagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
High-throughput quantification of 8 antihypertensive drugs and active metabolites in human plasma using UPLC-MS/MS.
2004
2004
Pharmacokinetics of canrenone after oral administration of spironolactone and intravenous injection of canrenoate-K in healthy man
SummaryFive healthy male volunteers received canrenoate-K 200 mg (Sincomen® pro injectione) by intravenous injection and one week… 
2002
2002
Cardiovascular effects of canrenone in patients with preascitic cirrhosis
In patients with cirrhosis and portal hypertension, standing induces a reduction in cardiac index (CI) and an increase in… 
2000
2000
High-performance liquid chromatographic optimization study for the separation of natural and synthetic anabolic steroids. Application to urine and pharmaceutical samples.
1998
1998
High-performance liquid chromatography methods for the separation and quantitation of spironolactone and its degradation products in aqueous formulations and of its metabolites in rat serum.
1990
1990
Influence of Spironolactone and Its Metabolite Canrenone on Serum Digoxin Assays
Although current immunoassay kits for digoxin supposedly have antibodies of high specificity, serum digoxin levels in patients… 
1985
1985
Determination of the serum concentration of spironolactone and its metabolites by high-performance liquid chromatography.
1978
1978
Relation of canrenone to the actions of spironolactone on adrenal cytochrome P-450 dependent enzymes.
Studies were carried out to determine the actions of spironolactone (SL) and its metabolite, canrenone, on adrenal mixed function… 
Highly Cited
1976
Highly Cited
1976
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria.
Effects of spironolactone, canrenone and canrenoate-K on adrenal cytochrome P450 (P450) and corticosteroid biosynthesis were… 
Highly Cited
1972
Highly Cited
1972
Isolation and identification of novel sulfur-containing metabolites of spironolactone (Aldactone).
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