Canrenone

Known as: Aldadiene, Canrenone [Chemical/Ingredient], Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone, (17alpha)-

An aldosterone antagonist with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor…

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.

1978

We measured the cross reactivity of two medications--digitoxin and spironolactone--in two digoxin radioimmunoassay (liquid and…

1977

Twenty patients receiving a constant maintenance therapy of digoxin preparations were selected, and daily plasma digoxin…

1976

time when the standing blood pressure was lowered. In these ten normotensive volunteers who received a single oral dose of…

1976

Canrenone can be determined by high-speed liquid chromatography in pharmaceutical dosage forms without interference from common…

1976

The absorption of canrenone, the major metabolite of spironolactone, was studied by a simple fluorometric method in 30 healthy…

1976

The activity of hexobarbital oxidase in vivo was found to be higher in rats forced to swim regularly (sleeping time studies). The…

1974

1972

SummaryThe effective refractory period (RP) of the right ventricle was measured in patients during routine heart catheterisation…

1971

The kinetics of the hydrolysis of the lactone canrenone, 3-(3-oxo-17β-hydroxy-4,6-androstadien-17α-yl)propionic acid γ-lactone…

1971

SummaryThe cardiac effect of an intravenous injection of 400 mg Aldadienepotassium (Aldactone pro injectione) was investigated in…