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- Publications
- Influence
[Clinical pharmacokinetics].
- L. Balant, C. Revillard, E. R. Garrett
- Medicine
- Schweizerische medizinische Wochenschrift
- 1976
The action of a drug depends on the quantity which reaches the site of its pharmacological action and how long it remains there. The necessary vital processes of the body dilute the active principle… Expand
Physicochemical Properties, Solubility, and Protein Binding of Δ9 -Tetrahydrocannabinol
- E. R. Garrett, C. A. Hunt
- Chemistry
- 1 July 1974
The rate and extent of glass binding of Δ9 -tetrahydrocannabinol in aqueous solution depend on the surface area and pretreatment of glass and the concentration of the drug. A total of 20 and 40% at… Expand
Pharmacokinetics of morphine and its surrogates. X: Analyses and pharmacokinetics of buprenorphine in dogs.
- E. R. Garrett, V. R. Chandran
- Chemistry, Medicine
- Biopharmaceutics & drug disposition
- 1 May 1990
Specific and sensitive reverse-phase HPLC assays of buprenorphine and its metabolite in biological fluids were developed with sensitivities of 2-6 ng ml-1 using fluorimetric detection.… Expand
Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans
- P. Hinderling, E. R. Garrett
- Chemistry, Medicine
- Journal of Pharmacokinetics and Biopharmaceutics
- 1 June 1976
The pharmacokinetics of the antiarrhythmic disopyramide, 4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide phosphate, and its monodealkylated metabolite were investigated in seven volunteers after… Expand
Protein binding and erythrocyte partitioning of disopyramide and its monodealkylated metabolite.
- P. Hinderling, J. Brès, E. R. Garrett
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 November 1974
Abstract The plasma protein binding of disopyramide, determined by equilibrium dialysis and ultrafiltration, is saturable; the fraction bound to human plasma protein varied from 0.05 to 0.65 with… Expand
Separation and spectrofluorometric assay of the -adrenergic blocker sotalol from blood and urine.
- E. R. Garrett, K. Schnelle
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 June 1971
Abstract A sensitive spectrofluorometric assay of sotalol·HCl ( d,l -4-(2-isopropylamino-1-hydroxyethyl)methanesulfonanilide hydrochloride; MJ 1999), a potent and specific β-adrenergic blocking… Expand
The Bateman function revisited: A critical reevaluation of the quantitative expressions to characterize concentrations in the one compartment body model as a function of time with first-order…
- E. R. Garrett
- Mathematics, Medicine
- Journal of Pharmacokinetics and Biopharmaceutics
- 1 April 1994
AbstractThe Bateman function,
$$A''(e^{ - k_e t} - e^{ - k_a t} )$$
, quantifies the time course of a first-order invasion (rate constant ka) to, and a first-order elimination (rate constant ke)… Expand
Physiochemical properties, solubility, and protein binding of delta9-tetrahydrocannabinol.
- E. R. Garrett, C. A. Hunt
- Medicine
- Journal of pharmaceutical sciences
- 1974
Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters.
- E. R. Garrett, H. Lambert
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 April 1973
The pharmacokinetics of intravenously administered trichloroethanol, chloral hydrate, sodium trichloroacetate, and trichloroethanol glucuronide were studied in the dog with developed GC analyses of… Expand
Kinetics and mechanisms of drug action of microorganisms XXIII: microbial kinetic assay for fluorouracil in biological fluids and its application to human pharmacokinetics.
- E. R. Garrett, G. Hurst, J. Green
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 October 1977
The apparent first-order generation rate constant, kapp, of Escherichia coli is a function of fluorouracil concentration, C, i.e., 1/(k0 − kapp) = k1(1/C) + k2, where k0 is the constant in the… Expand
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