• Publications
  • Influence
[Clinical pharmacokinetics].
The action of a drug depends on the quantity which reaches the site of its pharmacological action and how long it remains there. The necessary vital processes of the body dilute the active principleExpand
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Physicochemical Properties, Solubility, and Protein Binding of Δ9 -Tetrahydrocannabinol
The rate and extent of glass binding of Δ9 -tetrahydrocannabinol in aqueous solution depend on the surface area and pretreatment of glass and the concentration of the drug. A total of 20 and 40% atExpand
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Pharmacokinetics of morphine and its surrogates. X: Analyses and pharmacokinetics of buprenorphine in dogs.
Specific and sensitive reverse-phase HPLC assays of buprenorphine and its metabolite in biological fluids were developed with sensitivities of 2-6 ng ml-1 using fluorimetric detection.Expand
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Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans
The pharmacokinetics of the antiarrhythmic disopyramide, 4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide phosphate, and its monodealkylated metabolite were investigated in seven volunteers afterExpand
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Protein binding and erythrocyte partitioning of disopyramide and its monodealkylated metabolite.
Abstract The plasma protein binding of disopyramide, determined by equilibrium dialysis and ultrafiltration, is saturable; the fraction bound to human plasma protein varied from 0.05 to 0.65 withExpand
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Separation and spectrofluorometric assay of the -adrenergic blocker sotalol from blood and urine.
Abstract A sensitive spectrofluorometric assay of sotalol·HCl ( d,l -4-(2-isopropylamino-1-hydroxyethyl)methanesulfonanilide hydrochloride; MJ 1999), a potent and specific β-adrenergic blockingExpand
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The Bateman function revisited: A critical reevaluation of the quantitative expressions to characterize concentrations in the one compartment body model as a function of time with first-order
  • E. R. Garrett
  • Mathematics, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1 April 1994
AbstractThe Bateman function, $$A''(e^{ - k_e t} - e^{ - k_a t} )$$ , quantifies the time course of a first-order invasion (rate constant ka) to, and a first-order elimination (rate constant ke)Expand
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Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters.
The pharmacokinetics of intravenously administered trichloroethanol, chloral hydrate, sodium trichloroacetate, and trichloroethanol glucuronide were studied in the dog with developed GC analyses ofExpand
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Kinetics and mechanisms of drug action of microorganisms XXIII: microbial kinetic assay for fluorouracil in biological fluids and its application to human pharmacokinetics.
The apparent first-order generation rate constant, kapp, of Escherichia coli is a function of fluorouracil concentration, C, i.e., 1/(k0 − kapp) = k1(1/C) + k2, where k0 is the constant in theExpand
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