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Somatic mutation

Known as: Somatic Mutation Abnormality, somatic mutations 
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though… 
National Institutes of Health

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31 relations
5q-syndromeACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2BCL2 geneChronic Lymphocytic Leukemia
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Papers overview

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Highly Cited
2019
Highly Cited
2019
COSMIC: the Catalogue Of Somatic Mutations In Cancer
Abstract COSMIC, the Catalogue Of Somatic Mutations In Cancer (https://cancer.sanger.ac.uk) is the most detailed and… 
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Highly Cited
2015
Highly Cited
2015
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive… 
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Highly Cited
2013
Highly Cited
2013
Signatures of mutational processes in human cancer
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is… 
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Highly Cited
2013
Highly Cited
2013
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically… 
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Highly Cited
2013
Highly Cited
2013
Somatic mutations of calreticulin in myeloproliferative neoplasms.
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the… 
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Highly Cited
2012
Highly Cited
2012
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and… 
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Highly Cited
2010
Highly Cited
2010
A comprehensive catalogue of somatic mutations from a human cancer genome
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth… 
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Highly Cited
2008
Highly Cited
2008
Somatic mutations affect key pathways in lung adenocarcinoma
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well… 
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Highly Cited
2007
Highly Cited
2007
Patterns of somatic mutation in human cancer genomes
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence… 
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Highly Cited
1993
Highly Cited
1993
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
SPONTANEOUS errors in DNA replication have been suggested to play a significant role in neoplastic transformation and to explain… 
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