Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 210,259,241 papers from all fields of science
Search
Sign In
Create Free Account
Somatic mutation
Known as:
Somatic Mutation Abnormality
, somatic mutations
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
31 relations
5q-syndrome
ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2
BCL2 gene
Chronic Lymphocytic Leukemia
Expand
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
S. Forbes
,
D. Beare
,
+14 authors
P. Campbell
Nucleic Acids Res.
2014
Corpus ID: 275837
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive…
Expand
Highly Cited
2013
Highly Cited
2013
Signatures of mutational processes in human cancer
L. Alexandrov
,
S. Nik-Zainal
,
+67 authors
M. Stratton
Nature
2013
Corpus ID: 3912427
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is…
Expand
Highly Cited
2013
Highly Cited
2013
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
K. Cibulskis
,
M. Lawrence
,
+7 authors
G. Getz
Nature Biotechnology
2013
Corpus ID: 1262157
Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically…
Expand
Highly Cited
2013
Highly Cited
2013
Somatic mutations of calreticulin in myeloproliferative neoplasms.
T. Klampfl
,
H. Gisslinger
,
+26 authors
R. Kralovics
New England Journal of Medicine
2013
Corpus ID: 14787432
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the…
Expand
Highly Cited
2012
Highly Cited
2012
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.
D. Koboldt
,
Qunyuan Zhang
,
+7 authors
R. Wilson
Genome Research
2012
Corpus ID: 18280129
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and…
Expand
Highly Cited
2010
Highly Cited
2010
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
R. Verhaak
,
K. Hoadley
,
+30 authors
D. Hayes
Cancer Cell
2010
Corpus ID: 21692235
Highly Cited
2010
Highly Cited
2010
A comprehensive catalogue of somatic mutations from a human cancer genome
E. Pleasance
,
R. K. Cheetham
,
+42 authors
M. Stratton
Nature
2010
Corpus ID: 205219335
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth…
Expand
Highly Cited
2008
Highly Cited
2008
Somatic mutations affect key pathways in lung adenocarcinoma
L. Ding
,
G. Getz
,
+87 authors
R. Wilson
Nature
2008
Corpus ID: 528799
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well…
Expand
Highly Cited
2007
Highly Cited
2007
Patterns of somatic mutation in human cancer genomes
C. Greenman
,
P. Stephens
,
+63 authors
M. Stratton
Nature
2007
Corpus ID: 4409256
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence…
Expand
Highly Cited
1993
Highly Cited
1993
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
Y. Ionov
,
María Angeles Peinado
,
S. Malkhosyan
,
D. Shibata
,
M. Perucho
Nature
1993
Corpus ID: 4254940
SPONTANEOUS errors in DNA replication have been suggested to play a significant role in neoplastic transformation and to explain…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE