Somatic mutation

Known as: Somatic Mutation Abnormality, somatic mutations 
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1940-2017
050019402016

Papers overview

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Highly Cited
2015
Highly Cited
2015
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive… (More)
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Highly Cited
2013
Highly Cited
2013
Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically… (More)
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Highly Cited
2013
Highly Cited
2013
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is… (More)
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Highly Cited
2012
Highly Cited
2012
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and… (More)
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Highly Cited
2011
Highly Cited
2011
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July… (More)
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Highly Cited
2010
Highly Cited
2010
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth… (More)
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Highly Cited
2008
Highly Cited
2008
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well… (More)
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Highly Cited
2007
Highly Cited
2007
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders… (More)
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Highly Cited
2004
Highly Cited
2004
The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the… (More)
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