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Somatic mutation

Known as: Somatic Mutation Abnormality, somatic mutations 
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though… 
National Institutes of Health

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31 relations
5q-syndromeACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2BCL2 geneChronic Lymphocytic Leukemia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive… 
Highly Cited
2013
Highly Cited
2013
Signatures of mutational processes in human cancer
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is… 
Highly Cited
2013
Highly Cited
2013
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically… 
Highly Cited
2013
Highly Cited
2013
Somatic mutations of calreticulin in myeloproliferative neoplasms.
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the… 
Highly Cited
2012
Highly Cited
2012
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and… 
Highly Cited
2010
Highly Cited
2010
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
Highly Cited
2010
Highly Cited
2010
A comprehensive catalogue of somatic mutations from a human cancer genome
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth… 
Highly Cited
2008
Highly Cited
2008
Somatic mutations affect key pathways in lung adenocarcinoma
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well… 
Highly Cited
2007
Highly Cited
2007
Patterns of somatic mutation in human cancer genomes
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence… 
Highly Cited
1993
Highly Cited
1993
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
SPONTANEOUS errors in DNA replication have been suggested to play a significant role in neoplastic transformation and to explain… 
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