FAQ

Somatic mutation

Known as: Somatic Mutation Abnormality, somatic mutations 
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1940-2017
050019402016

Related topics

Related topics

29 relations
5q-syndromeACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2BCL2 geneChronic Lymphocytic Leukemia
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Somatic mutation
Liver carcinoma
Chronic Lymphocytic Leukemia
Multiple Myeloma
Nephroblastoma
Pancreatic carcinoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
COSMIC: exploring the world's knowledge of somatic mutations in human cancer
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive… (More)
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Highly Cited
2013
Highly Cited
2013
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically… (More)
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Highly Cited
2013
Highly Cited
2013
Signatures of mutational processes in human cancer
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is… (More)
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Highly Cited
2012
Highly Cited
2012
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing.
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and… (More)
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Highly Cited
2011
Highly Cited
2011
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July… (More)
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Highly Cited
2010
Highly Cited
2010
A comprehensive catalogue of somatic mutations from a human cancer genome
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth… (More)
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Highly Cited
2008
Highly Cited
2008
Somatic mutations affect key pathways in lung adenocarcinoma
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well… (More)
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Highly Cited
2007
Highly Cited
2007
Patterns of somatic mutation in human cancer genomes
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence… (More)
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Highly Cited
2005
Highly Cited
2005
A gain-of-function mutation of JAK2 in myeloproliferative disorders.
BACKGROUND Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders… (More)
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Highly Cited
2004
Highly Cited
2004
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the… (More)
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