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Somatic mutation

Known as: Somatic Mutation Abnormality, somatic mutations 
Any mutation with an origin in cells that are not destined to become gametes. As a consequence, such mutations are not transmitted to progeny, though… 
National Institutes of Health

Related topics

Related topics

31 relations
5q-syndromeACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2BCL2 geneChronic Lymphocytic Leukemia

Papers overview

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Highly Cited
1998
Highly Cited
1998
Fas ligand—a double-edged sword
Highly Cited
1998
Highly Cited
1998
Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection.
Ig class switching usually occurs as a consequence of cognate interactions between antigen-specific B cells and CD4(+) alphabeta… 
Highly Cited
1997
Highly Cited
1997
Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression
In the Revised European American Lymphoma (REAL) classification, several subtypes of high‐grade lymphomas were combined in the… 
Review
1994
Review
1994
Generating the antibody repertoire in rabbit.
Highly Cited
1993
Highly Cited
1993
Residues that mediate DNA binding of autoimmune antibodies.
Somatic mutations to arginine (R) are a common feature of a subset of J558 H chain genes that code for the majority of high… 
Highly Cited
1992
Highly Cited
1992
Evidence for somatic selection of natural autoantibodies
Natural autoantibodies are primarily immunoglobulin M (IgM) antibodies that bind to a variety of self-antigens, including self… 
Review
1989
Review
1989
Genetically engineered antibody molecules.
Highly Cited
1980
Highly Cited
1980
Expression of a variant form of actin and additional polypeptide changes following chemical-induced in vitro neoplastic transformation of human fibroblasts.
Highly Cited
1977
Highly Cited
1977
Synthesis of multiple immunoglobulin classes by single lymphocytes.
Studies were conducted on the genetic control of immunoglobulin synthesis using human peripheral blood lymphocytes and mouse and… 
Highly Cited
1969
Highly Cited
1969
Genetics of somatic mammalian cells. IX. Quantitation of mutagenesis by physical and chemical agents
The system previously described for inducing single gene mutations in Chinese hamster cells has been extended to produce… 
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