Evidence for somatic selection of natural autoantibodies

  title={Evidence for somatic selection of natural autoantibodies},
  author={Thierry Martin and Stephen F Duffy and Dennis Anthony Carson and Thomas J. Kipps},
  journal={The Journal of Experimental Medicine},
  pages={983 - 991}
Natural autoantibodies are primarily immunoglobulin M (IgM) antibodies that bind to a variety of self-antigens, including self-IgG. Accounting for a large proportion of the early B cell repertoire, such polyspecific autoantibodies are speculated to contribute to the homeostasis and/or competence of the primary humoral immune system. Recent studies indicate that the leukemia cells from most patients with chronic lymphocytic leukemia (CLL) also express such IgM autoantibodies. Similarly, the… CONTINUE READING


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