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Small Inducible Cytokine B11

Known as: I-TAC protein, human, H174, Chemokine (C-X-C Motif) Ligand 11 
C-X-C motif chemokine 11 (94 aa, ~10 kDa) is encoded by the human CXCL11 gene. This protein plays a role in chemoattraction for interleukin-activated… 
National Institutes of Health

Related topics

Related topics

17 relations
Biologic DevelopmentCXCL11 geneCXCL11 wt AlleleCentral Nervous System

Broader (1)

Chemokine CXCL11

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
CXCR3 ligands in disease and therapy.
Highly Cited
2015
Highly Cited
2015
VEGF suppresses T‐lymphocyte infiltration in the tumor microenvironment through inhibition of NF‐κB‐induced endothelial activation
Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) signaling pathway is in clinical use, but its… 
Highly Cited
2009
Highly Cited
2009
Villitis of Unknown Etiology Is Associated with a Distinct Pattern of Chemokine Up-Regulation in the Feto-Maternal and Placental Compartments: Implications for Conjoint Maternal Allograft Rejection…
The co-presence of histoincompatible fetal and maternal cells is a characteristic of human placental inflammation. Villitis of… 
Highly Cited
2008
Highly Cited
2008
CXCR3 and CCR5 chemokines in induced sputum from patients with COPD.
BACKGROUND COPD is associated with increased numbers of CD4(+) and CD8(+) lymphocytes and macrophages in the small airways and… 
Highly Cited
2005
Highly Cited
2005
Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C.
Chronic infection with the hepatitis C virus (HCV) is associated with failures of T-cell-mediated immune clearance and with… 
Highly Cited
2004
Highly Cited
2004
Intracellular Domains of CXCR3 That Mediate CXCL9, CXCL10, and CXCL11 Function*
The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T cells that is activated by three ligands as… 
Highly Cited
2003
Highly Cited
2003
An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4
The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation… 
Highly Cited
2003
Highly Cited
2003
CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
The chemokines CXCL9, 10, and 11 exert their action via CXC chemokine receptor-3 (CXCR3), a receptor highly expressed on… 
Highly Cited
2001
Highly Cited
2001
Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation
Recruitment of activated T‐cells to the skin is a common feature in a wide variety of inflammatory skin diseases. As CXCR3… 
Highly Cited
2001
Highly Cited
2001
CXCR3 Internalization Following T Cell-Endothelial Cell Contact: Preferential Role of IFN-Inducible T Cell α Chemoattractant (CXCL11)1
Chemokine receptors are rapidly desensitized and internalized following ligand binding, a process that attenuates receptor… 
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