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Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4
TLDR
The bicyclams are, to the authors' knowledge, the first low molecular weight anti-HIV agents shown to act as potent and selective CXCR4 antagonists.
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Autocrine Production of IL-10 Mediates Defective IL-12 Production and NF-κB Activation in Tumor-Associated Macrophages1
TLDR
The data suggest that during tumor growth an IL-10-dependent pathway of diversion of macrophage function can be activated into the tumor microenvironment and results in the promotion of the IL- 10+ IL-12− phenotype of TAM.
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Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides
TLDR
A diagonal method to isolate N-terminal peptides from in vivo blocked proteins based on diagonal electrophoresis and diagonal chromatography is described.
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Human monocyte chemotactic proteins‐2 and ‐3: structural and functional comparison with MCP‐1
TLDR
In vitro, MCPs show different specific biological activities depending on the cell type and the chemokine tested, and MCP‐3 has the broadest range in that it activates monocytes, dendritic cells, lymphocytes, natural killer cells, eosinophils, basophil, and neutrophils.
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Chemokine/chemokine receptor nomenclature.
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Interleukin-8 and other CXC chemokines
Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.
TLDR
The complete crystal structure of MCP-2 is determined that contains both pGlu1 and an intact C-terminus, and both N-terminal regions are protected against protease degradation.
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CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN‐γ‐induced chemokines
TLDR
In conclusion, parasite‐induced IFN‐γ in the brain results in high local expression levels of specific chemokines for monocytes and lymphocytes, and the strain‐dependent susceptibility to develop CM is more related to the expression of CXCR3 in circulating leukocytes than to the chemokine expression levels in the head.
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Petunia hybrida S-proteins: ribonuclease activity and the role of their glycan side chains in self-incompatibility
TLDR
Deglycosylation studies with the enzyme peptide-N-glycosidase F (PNGase F) reveals differences in the number of N-linked glycan chains present on the four S-RNases, which suggests another role of the glycan moiety in the self-incompatibility mechanism.
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Identification by sequence analysis of chemotactic factors for monocytes produced by normal and transformed cells stimulated with virus, double‐stranded RNA or cytokine
A monocyte chemotactic activity was found to be released by various types of cultured human cells after appropriate stimulation: normal diploid fibroblasts, peripheral blood mononuclear cells or…
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