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SRS-A

Known as: SRS-A [Chemical/Ingredient], Slow Reacting Substance of Anaphylaxis 
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions… 
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (8)

2-norleukotriene D1Leukotriene C4Leukotriene D4leukotriene C-3
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.
Allergic pulmonary reactions in vivo lead to airway constriction and mucous secretion, whereas in vitro lung anaphylaxis lead to… 
Highly Cited
1983
Highly Cited
1983
Measuring leukotrienes of slow reacting substance of anaphylaxis: development of a specific radioimmunoassay.
Rabbits were immunized with leukotriene C4 (LTC4) coupled to thiolated keyhole limpet hemocyanin (KLH) by using 6-N… 
Highly Cited
1983
Highly Cited
1983
IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells
Mouse bone marrow-derived mast cells differentiated in vitro and sensitized with monoclonal IgE respond to antigen-initiated… 
Highly Cited
1981
Highly Cited
1981
Formation of novel hydroxylated eicosatetraenoic acids in preparations of human polymorphonuclear leukocytes
Highly Cited
1980
Highly Cited
1980
Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF).
Highly Cited
1980
Highly Cited
1980
Slow reacting substances (SRSs): the structure identification of SRSs from rat basophil leukaemia (RBL-1) cells.
Review
1980
Review
1980
Leukotrienes and Slow Reacting Substance of Anaphylaxis (SRS‐A)
In 1938 Feldberg & Kellaway demonstrated that perfusates from dog and monkey lungs, treated with cobra venom, induced sustained… 
Highly Cited
1973
Highly Cited
1973
Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine.
The capacity of prostaglandins to suppress the IgE-dependent antigen-induced release of histamine from human lung tissue requires… 
Highly Cited
1970
Highly Cited
1970
Biologic function of the Fc fragments of E myeloma protein.
Highly Cited
1960
Highly Cited
1960
The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shock
The release of histamine during anaphylaxis has been demonstrated in several species and various tissues, but it is well known… 
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