Leukotriene D4

Known as: Leukotriene D-4, Leukotriene D 4, Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))- 
One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage… (More)
National Institutes of Health

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13 relations
In BloodLeukotriene D4 MeasurementProcess of secretionagonists
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Broader (2)

Leukotrienes DSRS-A

Narrower (1)

iodinated azido-leukotriene D4

Papers overview

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Highly Cited
2013
Highly Cited
2013
Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production.
BACKGROUND Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part through cysteinyl leukotriene receptor 1… (More)
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Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… (More)
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Highly Cited
1999
Highly Cited
1999
Characterization of the human cysteinyl leukotriene CysLT1 receptor
The cysteinyl leukotrienes—leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE 4)—are important mediators of human… (More)
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Highly Cited
1995
Highly Cited
1995
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance.
The multidrug resistant cell lines HL60/AR and GLC4/ADR show high overexpression of the gene encoding the multidrug resistance… (More)
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Highly Cited
1994
Highly Cited
1994
Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma. ACCOLATE Asthma Trialists Group.
The efficacy of 6 wk of therapy with oral ICI 204,219, a selective leukotriene D4 (LTD4) receptor antagonist, was evaluated in… (More)
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Highly Cited
1990
Highly Cited
1990
Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4-receptor antagonist.
BACKGROUND Exercise is a common stimulus of bronchoconstriction in subjects with asthma, who also have bronchoconstriction after… (More)
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Highly Cited
1984
Highly Cited
1984
Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.
The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal… (More)
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Highly Cited
1983
Highly Cited
1983
Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin.
The local effects of intracutaneous injections into humans of 1-3 nmol of five products of arachidonic acid metabolism… (More)
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Highly Cited
1982
Highly Cited
1982
Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.
Allergic pulmonary reactions in vivo lead to airway constriction and mucous secretion, whereas in vitro lung anaphylaxis lead to… (More)
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Highly Cited
1980
Highly Cited
1980
Leukotrienes are potent constrictors of human bronchi
Slow reacting substance of anaphylaxis (SRS-A) is released by various stimuli, including immunological challenge, and has long… (More)
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