Leukotriene D4

Known as: Leukotriene D-4, Leukotriene D 4, Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))- 
One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part through cysteinyl leukotriene receptor 1… (More)
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Review
2007
Review
2007
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… (More)
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Highly Cited
1999
Highly Cited
1999
The cysteinyl leukotrienes—leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE 4)—are important mediators of human… (More)
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Highly Cited
1995
Highly Cited
1995
The multidrug resistant cell lines HL60/AR and GLC4/ADR show high overexpression of the gene encoding the multidrug resistance… (More)
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Highly Cited
1994
Highly Cited
1994
The efficacy of 6 wk of therapy with oral ICI 204,219, a selective leukotriene D4 (LTD4) receptor antagonist, was evaluated in… (More)
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Highly Cited
1990
Highly Cited
1990
BACKGROUND Exercise is a common stimulus of bronchoconstriction in subjects with asthma, who also have bronchoconstriction after… (More)
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Highly Cited
1984
Highly Cited
1984
The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal… (More)
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Highly Cited
1983
Highly Cited
1983
The local effects of intracutaneous injections into humans of 1-3 nmol of five products of arachidonic acid metabolism… (More)
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Highly Cited
1982
Highly Cited
1982
Allergic pulmonary reactions in vivo lead to airway constriction and mucous secretion, whereas in vitro lung anaphylaxis lead to… (More)
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Highly Cited
1980
Highly Cited
1980
Slow reacting substance of anaphylaxis (SRS-A) is released by various stimuli, including immunological challenge, and has long… (More)
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