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Leukotriene D4

Known as: Leukotriene D-4, Leukotriene D 4, Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))- 
One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage… Expand
National Institutes of Health

Related topics

Related topics

13 relations
In BloodLeukotriene D4 MeasurementProcess of secretionagonists
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Broader (2)

Leukotrienes DSRS-A

Narrower (1)

iodinated azido-leukotriene D4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms
Group 2 innate lymphoid cells (ILC2s) play critical roles in the induction of type 2 inflammation, response to parasite infection… Expand
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Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… Expand
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Review
2001
Review
2001
Cooperation of Liver Cells in Health and Disease
  • Z. Kmiec
  • Advances in Anatomy Embryology and Cell Biology
  • 2001
    • Corpus ID: 7714118
The liver lobule is formed by parenchymal cells, i.e., hepatocytes and nonparenchymal cells. In contrast to hepatocytes that… Expand
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Highly Cited
1999
Highly Cited
1999
Characterization of the human cysteinyl leukotriene CysLT1 receptor
The cysteinyl leukotrienes—leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE 4)—are important mediators of human… Expand
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Highly Cited
1995
Highly Cited
1995
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance.
The multidrug resistant cell lines HL60/AR and GLC4/ADR show high overexpression of the gene encoding the multidrug resistance… Expand
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Highly Cited
1994
Highly Cited
1994
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
The multidrug resistance-associated protein (MRP) is the product of an ATP-binding cassette transporter gene overexpressed in… Expand
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Highly Cited
1990
Highly Cited
1990
Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process.
The hypothesis that neutrophils play an important role in the pathogenesis of gastric ulceration induced by nonsteroidal anti… Expand
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Highly Cited
1984
Highly Cited
1984
Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.
The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal… Expand
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Highly Cited
1982
Highly Cited
1982
Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.
Allergic pulmonary reactions in vivo lead to airway constriction and mucous secretion, whereas in vitro lung anaphylaxis lead to… Expand
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Highly Cited
1980
Highly Cited
1980
Leukotrienes are potent constrictors of human bronchi
Slow reacting substance of anaphylaxis (SRS-A) is released by various stimuli, including immunological challenge, and has long… Expand
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