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SMO protein, human

Known as: SMOH, Smoothened, smoothened homolog (Drosophila), human 
Smoothened homolog (787 aa, ~86 kDa) is encoded by the human SMO gene. This protein plays a role in the modulation of hedgehog signaling pathways.
National Institutes of Health

Papers overview

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Review
2019
Review
2019
ABSTRACT Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue… Expand
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Highly Cited
2008
Highly Cited
2008
Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated with tumorigenesis in a number of human… Expand
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Highly Cited
2007
Highly Cited
2007
Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in… Expand
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Review
2006
Review
2006
Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily conserved, recent studies indicate that… Expand
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Highly Cited
2005
Highly Cited
2005
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a… Expand
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Highly Cited
2005
Highly Cited
2005
The intraflagellar transport (IFT) proteins Ift172/Wimple and Polaris/Ift88 and the anterograde IFT motor kinesin-II are required… Expand
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Highly Cited
2002
Highly Cited
2002
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block… Expand
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Highly Cited
2002
Highly Cited
2002
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic… Expand
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Highly Cited
1996
Highly Cited
1996
Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein… Expand
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