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SMO protein, human

Known as: SMOH, Smoothened, smoothened homolog (Drosophila), human 
Smoothened homolog (787 aa, ~86 kDa) is encoded by the human SMO gene. This protein plays a role in the modulation of hedgehog signaling pathways.
National Institutes of Health

Related topics

Related topics

17 relations
Axon GuidanceCiliaFrizzled DomainG Protein-Coupled Receptor Genes

Broader (1)

Smoothened Receptor

Papers overview

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Highly Cited
2011
Highly Cited
2011
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.
Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in… 
Highly Cited
2008
Highly Cited
2008
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.
Highly Cited
2008
Highly Cited
2008
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
MicroRNAs (miRNA) are crucial post‐transcriptional regulators of gene expression and control cell differentiation and… 
Highly Cited
2006
Highly Cited
2006
Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion
The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo… 
Highly Cited
2002
Highly Cited
2002
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block… 
Highly Cited
2000
Highly Cited
2000
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
Highly Cited
1999
Highly Cited
1999
Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain.
Adult rat-derived hippocampal progenitor cells express many of the molecules implicated in midbrain dopaminergic determination… 
Highly Cited
1999
Highly Cited
1999
Sonic hedgehog signaling by the Patched–Smoothened receptor complex
Highly Cited
1998
Highly Cited
1998
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants.
The expression of genes involved in the Sonic Hedgehog signalling pathway, including Shh, Ptc, Smo, Gli1, Gli2 and Gli3, were… 
Highly Cited
1996
Highly Cited
1996
Dual Roles for Patched in Sequestering and Transducing Hedgehog
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