SMO protein, human

Known as: SMOH, Smoothened, smoothened homolog (Drosophila), human 
Smoothened homolog (787 aa, ~86 kDa) is encoded by the human SMO gene. This protein plays a role in the modulation of hedgehog signaling pathways.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Toward the goal of generating a mouse medulloblastoma model with increased tumor incidence, we developed a homozygous version of… (More)
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Highly Cited
2008
Highly Cited
2008
Ligand-dependent activation of the hedgehog (Hh) signalling pathway has been associated with tumorigenesis in a number of human… (More)
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Review
2006
Review
2006
Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily conserved, recent studies indicate that… (More)
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Highly Cited
2005
Highly Cited
2005
Sonic Hedgehog (Shh) signals are transduced into nuclear ratios of Gli transcriptional activator versus repressor. The initial… (More)
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Highly Cited
2005
Highly Cited
2005
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a… (More)
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Highly Cited
2002
Highly Cited
2002
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block… (More)
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Highly Cited
2000
Highly Cited
2000
Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the… (More)
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Highly Cited
1998
Highly Cited
1998
Basal-cell carcinomas (BCCs) are the commonest human cancer. Insight into their genesis came from identification of mutations in… (More)
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Highly Cited
1996
Highly Cited
1996
Smoothened (smo) is a segment polarity gene required for correct patterning of every segment in Drosophila. The earliest defect… (More)
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Highly Cited
1996
Highly Cited
1996
Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein… (More)
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