Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

@article{Dierks2008ExpansionOB,
  title={Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.},
  author={Christine Dierks and R Mohamad Beigi and Gui-rong Guo and Katja Zirlik and Mario Reinhard Stegert and Paul E. Manley and Christopher M Trussell and Annette Schmitt-Graeff and Klemens Landwerlin and Hendrik Dr Veelken and Markus Warmuth},
  journal={Cancer cell},
  year={2008},
  volume={14 3},
  pages={
          238-49
        }
}
Resistance of Bcr-Abl-positive leukemic stem cells (LSCs) to imatinib treatment in patients with chronic myeloid leukemia (CML) can cause relapse of disease and might be the origin for emerging drug-resistant clones. In this study, we identified Smo as a drug target in Bcr-Abl-positive LSCs. We show that Hedgehog signaling is activated in LSCs through upregulation of Smo. While Smo(-/-) does not impact long-term reconstitution of regular hematopoiesis, the development of retransplantable Bcr… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 260 CITATIONS, ESTIMATED 63% COVERAGE

9 Epithelial-Mesenchymal Transition and Cancer Stem Cells

VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Novel combination treatments targeting chronic myeloid leukemia stem cells.

  • Clinical lymphoma, myeloma & leukemia
  • 2012
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies

  • Journal of Hematology & Oncology
  • 2014
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 19 Highly Influenced Citations

  • Averaged 13 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

InhibitionofHedgehog by directbindingof cyclopamine to Smoothened

J. K. Chen, J. Taipale, M. K. Cooper, P. A. andBeachy
  • GenesDev .
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Hedgehog is required for murine yolk sac angiogenesis.

  • Development
  • 2002
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers