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Frizzled Domain

Known as: Frizzled CRD, Frizzled Cysteine-Rich Domain, Fz Domain 
A 120 amino acid protein domain, with an alpha-helical structure, containing 10 cysteines, which have conserved spacing throughout the sequence. This… Expand
National Institutes of Health

Papers overview

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2017
2017
Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically… Expand
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2014
2014
Frizzleds (FZDs) are transmembrane receptors in the Wnt signaling pathway and they play pivotal roles in developments. The… Expand
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2012
2012
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can… Expand
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Highly Cited
2011
Highly Cited
2011
Constitutive activation of Wnt/β-catenin signaling in cancer results from mutations in pathway components, which frequently… Expand
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2009
2009
Muscle-specific kinase (MuSK) is an essential receptor tyrosine kinase for the establishment and maintenance of the neuromuscular… Expand
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2009
2009
The molecular details of how cholesterol exits lysosomes and is integrated into cellular and endoplasmic reticulum membranes… Expand
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2007
2007
Canonical WNT signals are transduced through Frizzled (FZD) family receptor and LRP5/LRP6 co-receptor to upregulate FGF20, JAG1… Expand
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2007
2007
Canonical WNT signals are transduced through Frizzled (FZD) family receptor and LRP5/LRP6 co-receptor to upregulate MYC, CCND1… Expand
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2005
2005
Transmembrane proteins with extracellular Frizzled domain, such as ROR1, ROR2, MUSK, MFRP, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6… Expand
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Highly Cited
1997
Highly Cited
1997
Convincing evidence has accumulated to identify the Frizzled proteins as receptors for the Wnt growth factors. In parallel, a… Expand
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