Frizzled Domain

Known as: Frizzled CRD, Frizzled Cysteine-Rich Domain, Fz Domain 
A 120 amino acid protein domain, with an alpha-helical structure, containing 10 cysteines, which have conserved spacing throughout the sequence. This… (More)

Topic mentions per year

Topic mentions per year

1998-2017
01219982017

Papers overview

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2017
2017
Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically… (More)
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2016
2016
Secreted frizzled related protein 3 (SFRP3) contains a cysteine-rich domain (CRD) that shares homology with Frizzled CRD and… (More)
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2015
2015
Wnt/Frizzled signaling is involved in many developmental processes but is mostly silent in healthy adult organs. However, a… (More)
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2013
2013
Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened… (More)
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2012
2012
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can… (More)
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Highly Cited
2001
Highly Cited
2001
Members of the Frizzled family of seven-pass transmembrane proteins serve as receptors for Wnt signalling proteins. Wnt proteins… (More)
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Review
1998
Review
1998
Genes of the frizzled family have been found in many animal species. They encode seven-transmembrane proteins which act as… (More)
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