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Frizzled Domain

Known as: Frizzled CRD, Frizzled Cysteine-Rich Domain, Fz Domain 
A 120 amino acid protein domain, with an alpha-helical structure, containing 10 cysteines, which have conserved spacing throughout the sequence. This… Expand
National Institutes of Health

Related topics

Related topics

13 relations
FZD1 protein, humanFZD2 protein, humanFZD3 protein, humanFZD4 protein, human
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Papers overview

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2017
2017
Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains
Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically… Expand
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2014
2014
The evolutionary analysis reveals domain fusion of proteins with Frizzled-like CRD domain.
Frizzleds (FZDs) are transmembrane receptors in the Wnt signaling pathway and they play pivotal roles in developments. The… Expand
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2012
2012
Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can… Expand
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Highly Cited
2011
Highly Cited
2011
Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin
Constitutive activation of Wnt/β-catenin signaling in cancer results from mutations in pathway components, which frequently… Expand
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2009
2009
Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.
Muscle-specific kinase (MuSK) is an essential receptor tyrosine kinase for the establishment and maintenance of the neuromuscular… Expand
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2009
2009
Structural Ties between Cholesterol Transport and Morphogen Signaling
The molecular details of how cholesterol exits lysosomes and is integrated into cellular and endoplasmic reticulum membranes… Expand
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2007
2007
Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet…
Canonical WNT signals are transduced through Frizzled (FZD) family receptor and LRP5/LRP6 co-receptor to upregulate FGF20, JAG1… Expand
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2007
2007
Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs.
Canonical WNT signals are transduced through Frizzled (FZD) family receptor and LRP5/LRP6 co-receptor to upregulate MYC, CCND1… Expand
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2005
2005
Comparative genomics on ROR1 and ROR2 orthologs.
Transmembrane proteins with extracellular Frizzled domain, such as ROR1, ROR2, MUSK, MFRP, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6… Expand
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Highly Cited
1997
Highly Cited
1997
The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.
Convincing evidence has accumulated to identify the Frizzled proteins as receptors for the Wnt growth factors. In parallel, a… Expand
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