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Frizzled Domain
Known as:
Frizzled CRD
, Frizzled Cysteine-Rich Domain
, Fz Domain
A 120 amino acid protein domain, with an alpha-helical structure, containing 10 cysteines, which have conserved spacing throughout the sequence. This…
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National Institutes of Health
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Related topics
Related topics
13 relations
FZD1 protein, human
FZD2 protein, human
FZD3 protein, human
FZD4 protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Novel ROR1 inhibitor ARI-1 suppresses the development of non-small cell lung cancer.
Xuesha Liu
,
Wenchen Pu
,
+13 authors
Yong Peng
Cancer letters
2019
Corpus ID: 164217183
2017
2017
Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains
Mark Agostino
,
S. Pohl
,
A. Dharmarajan
The Journal of Biological Chemistry
2017
Corpus ID: 24414227
Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically…
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2012
2012
Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
I. Hendaoui
,
E. Lavergne
,
+6 authors
O. Musso
PloS one
2012
Corpus ID: 18528684
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can…
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Highly Cited
2011
Highly Cited
2011
Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin
E. Lavergne
,
I. Hendaoui
,
+7 authors
O. Musso
Oncogene
2011
Corpus ID: 11647758
Constitutive activation of Wnt/β-catenin signaling in cancer results from mutations in pathway components, which frequently…
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2009
2009
Structural Ties between Cholesterol Transport and Morphogen Signaling
J. Bazan
,
F. Sauvage
Cell
2009
Corpus ID: 16874728
Highly Cited
2009
Highly Cited
2009
Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.
A. L. Stiegler
,
S. Burden
,
S. Hubbard
Journal of molecular biology
2009
Corpus ID: 16003503
2007
2007
Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet…
Y. Katoh
,
M. Katoh
International journal of oncology
2007
Corpus ID: 34811301
Canonical WNT signals are transduced through Frizzled (FZD) family receptor and LRP5/LRP6 co-receptor to upregulate FGF20, JAG1…
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2005
2005
Comparative genomics on ROR1 and ROR2 orthologs.
Masuko Katoh
,
M. Katoh
Oncology reports
2005
Corpus ID: 44624095
Transmembrane proteins with extracellular Frizzled domain, such as ROR1, ROR2, MUSK, MFRP, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6…
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1998
1998
Cloning, sequence analysis, and distribution of rat metallocarboxypeptidase Z.
X. Xin
,
R. Day
,
W. Dong
,
Y. Lei
,
L. Fricker
DNA and cell biology
1998
Corpus ID: 6571182
A cDNA encoding human carboxypeptidase Z (CPZ), a novel metallocarboxypeptidase, was recently cloned (Song and Fricker, J. Biol…
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Highly Cited
1997
Highly Cited
1997
The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.
K. Lin
,
S. Wang
,
Martin A. Julius
,
J. Kitajewski
,
M. Moos
,
F. Luyten
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 23846243
Convincing evidence has accumulated to identify the Frizzled proteins as receptors for the Wnt growth factors. In parallel, a…
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