FAQ

Frizzled Domain

Known as: Frizzled CRD, Frizzled Cysteine-Rich Domain, Fz Domain 
A 120 amino acid protein domain, with an alpha-helical structure, containing 10 cysteines, which have conserved spacing throughout the sequence. This… (More)

Topic mentions per year

Topic mentions per year

1998-2017
01219982017

Related topics

Related topics

13 relations
FZD1 protein, humanFZD2 protein, humanFZD3 protein, humanFZD4 protein, human
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Related mentions per year

Related mentions per year

1974-2018
197019801990200020102020
Frizzled Domain
SMO protein, human
FZD4 protein, human
MUSK protein, human
FZD2 protein, human
frizzled related protein-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains.
Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically… (More)
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2016
2016
Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients.
Secreted frizzled related protein 3 (SFRP3) contains a cysteine-rich domain (CRD) that shares homology with Frizzled CRD and… (More)
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2015
2015
Novel Peptides that Block the Interaction between Wnt and Frizzled
Wnt/Frizzled signaling is involved in many developmental processes but is mostly silent in healthy adult organs. However, a… (More)
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2013
2013
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.
Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened… (More)
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2012
2012
Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can… (More)
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2012
2012
Correction: Inhibition of Wnt/β-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8
 
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Highly Cited
2001
Highly Cited
2001
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Members of the Frizzled family of seven-pass transmembrane proteins serve as receptors for Wnt signalling proteins. Wnt proteins… (More)
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Review
1998
Review
1998
The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases
Genes of the frizzled family have been found in many animal species. They encode seven-transmembrane proteins which act as… (More)
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