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Frizzled Domain

Known as: Frizzled CRD, Frizzled Cysteine-Rich Domain, Fz Domain 
A 120 amino acid protein domain, with an alpha-helical structure, containing 10 cysteines, which have conserved spacing throughout the sequence. This… Expand
National Institutes of Health

Papers overview

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2017
2017
Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically… Expand
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2014
2014
Frizzleds (FZDs) are transmembrane receptors in the Wnt signaling pathway and they play pivotal roles in developments. The… Expand
2012
2012
The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can… Expand
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Highly Cited
2011
Highly Cited
2011
Constitutive activation of Wnt/β-catenin signaling in cancer results from mutations in pathway components, which frequently… Expand
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2009
2009
The molecular details of how cholesterol exits lysosomes and is integrated into cellular and endoplasmic reticulum membranes… Expand
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Highly Cited
2009
Highly Cited
2009
Muscle-specific kinase (MuSK) is an essential receptor tyrosine kinase for the establishment and maintenance of the neuromuscular… Expand
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2007
2007
Canonical WNT signals are transduced through Frizzled (FZD) family receptor and LRP5/LRP6 co-receptor to upregulate FGF20, JAG1… Expand
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2005
2005
Transmembrane proteins with extracellular Frizzled domain, such as ROR1, ROR2, MUSK, MFRP, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6… Expand
1998
1998
A cDNA encoding human carboxypeptidase Z (CPZ), a novel metallocarboxypeptidase, was recently cloned (Song and Fricker, J. Biol… Expand
Highly Cited
1997
Highly Cited
1997
Convincing evidence has accumulated to identify the Frizzled proteins as receptors for the Wnt growth factors. In parallel, a… Expand
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