Smoothened Receptor

Known as: Receptor, Smoothened, Smoothened Receptor [Chemical/Ingredient], Receptors, Smoothened 
A frizzled-like, G-protein-coupled receptor that associates with PATCHED RECEPTORS to transduce signals from HEDGEHOG PROTEINS and initiate hedgehog… (More)

Topic mentions per year

Topic mentions per year

2009-2016
01220092016

Papers overview

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2017
2017
We present herein a novel dissection-then-evolution strategy for ligand optimization. Using the co-crystal structure of the… (More)
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2016
2016
The sonic hedgehog (Shh) signaling pathway plays a fundamental role in the central nervous system (CNS) development, but its… (More)
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2016
2016
The dissociation rates of unlabeled drugs have been well studied by kinetic binding analyses. Since kinetic assays are laborious… (More)
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2015
2015
OBJECTIVE The aim of this study was to investigate the expression of smoothened protein (Smo), a sonic hedgehog (Shh) signalling… (More)
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2015
2015
Hedgehog (Hh) signaling critical for development, differentiation, and cell growth is involved in several cancers, including… (More)
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2014
2014
BACKGROUND The smoothened (SMO) receptor, one of the Class F G protein coupled receptors (GPCRs), is an essential component of… (More)
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2009
2009
INTRODUCTION Medulloblastomas, that are believed to arise from granule-cell precursors (GCP), are the most frequently diagnosed… (More)
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