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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
TLDR
It is shown that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neuroGenesis after endotoxin-induced inflammation and augments neurogenescence after cranial irradiation.
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Vascular niche for adult hippocampal neurogenesis
TLDR
The present data provide the first evidence that adult neurogenesis occurs within an angiogenic niche and may provide a novel interface where mesenchyme‐derived cells and circulating factors influence plasticity in the adult central nervous system.
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Functional neurogenesis in the adult hippocampus
TLDR
It is reported that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells.
View on Springer
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
TLDR
The distribution and incidence of BrdU labeling matched those of the 4 week post injection groups, suggesting that proliferating cells dividein situ rather than migrate from the ependymal zone, and that glial progenitors exist in the outer circumference of the spinal cord that can give rise to both astrocyte and oligodendrocytes.
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Irradiation induces neural precursor-cell dysfunction
TLDR
It is shown that the deficit in neurogenesis reflects alterations in the microenvironment that regulates progenitor-cell fate, as well as a defect in the proliferative capacity of the neural progenitors in the irradiated hippocampus.
View on Nature
VEGF is necessary for exercise‐induced adult hippocampal neurogenesis
TLDR
In evaluating the signalling that running provides to the central nervous system in mice, it is found that peripheral vascular endothelial growth factor (VEGF) is necessary for the effects of running on adult hippocampal neurogenesis and that these somatic signalling networks can function independently of the central regulatory networks that are typically considered in the context of hippocampal neuroscience.
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Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.
TLDR
It is indicated that FGF-2 responsive progenitors can be isolated from the adult hippocampus and that these cells retain the capacity to generate mature neurons when grafted into the adult rat brain.
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Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells
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The Adult Rat Hippocampus Contains Primordial Neural Stem Cells
TLDR
The ability to genetically mark and clone normal diploid hippocampal progenitors provides the first definitive evidence that multipotent neural stem cells exist outside of the adult striatal subventricular zone and supports the hypothesis that FGF-2-responsive neural stem Cells may be broadly distributed in the adult brain.
View on Elsevier
Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS
TLDR
The recruitment of similar FGF-2-responsive cells from the adult optic nerve, a structure well isolated from the neurogenic zones within the brain, confirmed that neuron-competent precursors naturally exist in widely divergent tissues of the adult brain.
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