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SLCO1B1 gene

Known as: solute carrier organic anion transporter family member 1B1, LIVER-SPECIFIC TRANSPORTER 1, OATP-C 
This gene is involved in sodium-independent uptake of numerous endogenous compounds in the liver.
National Institutes of Health

Related topics

Related topics

8 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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Highly Cited
2011
Highly Cited
2011
Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors
The purpose of this study was to investigate the effect of genetic variations in organic anion-transporting polypeptide 1B1… 
Highly Cited
2008
Highly Cited
2008
Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide
Objective Organic anion transporting polypeptide 1B1 (OATP1B1), encoded by SLCO1B1, is an influx transporter expressed on the… 
Highly Cited
2007
Highly Cited
2007
SLCO1B1 521T-->C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients.
AIMS Pravastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is widely used both in primary… 
Highly Cited
2005
Highly Cited
2005
Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17
Objective The aim was to investigate whether polymorphisms in the SLCO1B1 gene, encoding the hepatic uptake transporter OATP1B1… 
Highly Cited
2005
Highly Cited
2005
Comparative Pharmacophore Modeling of Organic Anion Transporting Polypeptides: A Meta-Analysis of Rat Oatp1a1 and Human OATP1B1
The organic anion transporting polypeptides OATPs are key membrane transporters for which crystal structures are not currently… 
Highly Cited
2004
Highly Cited
2004
Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).
OBJECTIVE Two kinds of single nucleotide polymorphism (SNP; Asn130Asp and Val174Ala) are frequently observed in the liver… 
Highly Cited
2004
Highly Cited
2004
Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat.
Physiological cholestasis linked to immature hepatobiliary transport systems for organic anions occurs in rat and human neonates… 
Highly Cited
1999
Highly Cited
1999
Pravastatin, an HMG-CoA Reductase Inhibitor, Is Transported by Rat Organic Anion Transporting Polypeptide, oatp2
AbstractPurpose. We previously demonstrated the HMG-CoA reductase inhibitor, pravastatin, is actively taken up into isolated rat… 
Highly Cited
1996
Highly Cited
1996
Immunologic distribution of an organic anion transport protein in rat liver and kidney.
A Na(+)-independent organic anion transport protein was recently cloned from rat liver using a Xenopus laevis oocyte expression… 
Highly Cited
1969
Highly Cited
1969
Multiplicity of Hepatic Excretory Mechanisms for Organic Anions
Previous studies based upon competition between different organic anions for biliary excretion in vivo have suggested that all… 
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