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SLCO1B1 gene

Known as: solute carrier organic anion transporter family member 1B1, LIVER-SPECIFIC TRANSPORTER 1, OATP-C 
This gene is involved in sodium-independent uptake of numerous endogenous compounds in the liver.
National Institutes of Health

Related topics

Related topics

8 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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Highly Cited
2011
Highly Cited
2011
Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors
The purpose of this study was to investigate the effect of genetic variations in organic anion-transporting polypeptide 1B1… 
2010
2010
OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers
Purpose:  To investigate the contribution of the most frequent single nucleotide polymorphism (SNPs) of the organic anion… 
Highly Cited
2008
Highly Cited
2008
Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide
Objective Organic anion transporting polypeptide 1B1 (OATP1B1), encoded by SLCO1B1, is an influx transporter expressed on the… 
Highly Cited
2008
Highly Cited
2008
No significant effect of SLCO1B1 polymorphism on the pharmacokinetics of rosiglitazone and pioglitazone.
AIMS To examine possible effects of polymorphism in the SLCO1B1 gene, encoding the hepatic uptake transporter organic anion… 
Highly Cited
2007
Highly Cited
2007
SLCO1B1 521T-->C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients.
AIMS Pravastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is widely used both in primary… 
2007
2007
Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute [corrected] renal failure.
The effect of acute renal failure (ARF) induced by ischemia/reperfusion (I/R) of rat kidney on the expression of organic anion… 
2007
2007
Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes.
Highly Cited
2004
Highly Cited
2004
Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat.
Physiological cholestasis linked to immature hepatobiliary transport systems for organic anions occurs in rat and human neonates… 
Highly Cited
1971
Highly Cited
1971
Phylogenetic study of organic anion transfer from plasma into the liver.
THE discovery of two intracellular proteins, Y and Z, with the unique property of binding certain organic anions, may help to… 
Highly Cited
1969
Highly Cited
1969
Multiplicity of Hepatic Excretory Mechanisms for Organic Anions
Previous studies based upon competition between different organic anions for biliary excretion in vivo have suggested that all… 
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