Drug interactions with lipid‐lowering drugs: Mechanisms and clinical relevance
Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake
Current knowledge about the expression, function, substrate characteristics, and pharmacogenetics of OATP1B1 as well as its role in drug interactions are reviewed, in parts comparing with those of other hepatocyte-expressed organic anion transporting polypeptides, OATp1B3 and O ATP2B1.
Gemfibrozil greatly increases plasma concentrations of cerivastatin
- J. Backman, Carl Kyrklund, M. Neuvonen, P. Neuvonen
- Medicine, BiologyClinical pharmacology and therapy
- 1 December 2002
The effect of gemfibrozil on cerivastatin pharmacokinetics was studied to study the mechanism of this potentially fatal drug interaction.
Polymorphic Organic Anion Transporting Polypeptide 1B1 is a Major Determinant of Repaglinide Pharmacokinetics
Cyclosporine markedly raises the plasma concentrations of repaglinide
SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid
- M. Pasanen, M. Neuvonen, P. Neuvonen, M. Niemi
- Biology, MedicinePharmacogenetics & Genomics
- 1 December 2006
Raised plasma concentrations of simvastatin acid in patients carrying the SLCO1B1 c.521C variant allele may enhance the risk of systemic adverse effects during simVastatin treatment and reduce its cholesterol-lowering efficacy, respectively.
Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.
- L. Kajosaari, J. Laitila, P. Neuvonen, J. Backman
- Biology, ChemistryBasic & Clinical Pharmacology & Toxicology
- 1 October 2005
Both CYP2C8 and CYP3A4 are important in the metabolism of therapeutic concentrations of repaglinide in vitro, but their predicted contributions in vivo are highly dependent on the scaling factor used.
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).
This study aimed to characterize possible relationships between polymorphisms in the drug transporter genes organic anion transporting polypeptide-C (OATP-C, SLCO1B1), OATP-B (SLCO2B1), multidrug…
Pharmacokinetics of metformin after intravenous and oral administration to man
- P. Pentikäinen, P. Neuvonen, A. Penttilä
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
- 1 September 1979
The kinetics of14C-metformin have been studied in five healthy subjects after oral and intravenous administration, which resulted in a plasma concentration profile of “flip-flop” type for oral metformin.
The area under the plasma concentration–time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin
- J. Backman, K. Kivistö, K. Olkkola, P. Neuvonen
- Biology, MedicineEuropean Journal of Clinical Pharmacology
- 1 March 1998
Switching from inhibition to induction of cytochrome P450 3A (CYP3A) enzymes causes a very great change in the AUC of oral midazolam, which is greatly decreased by itraconazole and increased by rifampicin.