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SLC7A5 gene

Known as: MEMBRANE PROTEIN E16, CD98, SLC7A5 
This gene plays a role in high-affinity transport of large neutral amino acids.
National Institutes of Health

Related topics

Related topics

9 relations
CD98 AntigenHomo sapiensIonophore activityLarge Neutral Amino Acids Transporter Small Subunit 1, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
The L-type amino acid transporter 1 (LAT1, SLC7A5) transports essential amino acids across the blood-brain barrier (BBB) and into… Expand
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2014
2014
System l amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-l-tyrosine (FET)
O-(2-fluoroethyl)-l-tyrosine (FET) labeled with fluorine-18 is an important and specific tracer for diagnostics of glioblastoma… Expand
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2013
2013
Transport of gabapentin by LAT1 (SLC7A5).
Gabapentin is used in the treatment of epilepsy and neuropathic pain. Gabapentin has high and saturable permeability across the… Expand
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2013
2013
Maternal Transfer of the Cyanobacterial Neurotoxin β-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) has been implicated in the etiology of neurodegenerative disease… Expand
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2007
2007
Targeting the Cerebrovascular Large Neutral Amino Acid Transporter (LAT1) Isoform Using a Novel Disulfide-Based Brain Drug Delivery System
We describe a novel strategy to achieve high affinity recognition for the specific, cerebrovascular large neutral amino acid… Expand
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Review
2001
Review
2001
Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance.
In the last decade, a lot of amino acid transporters were identified by molecular cloning and assigned to the classically… Expand
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2001
2001
Predominant functional activity of the large, neutral amino acid transporter (LAT1) isoform at the cerebrovasculature
In this study, we identify the predominant functional expression of the large, neutral amino acid transporter (LAT1) isoform at… Expand
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2001
2001
Uteroplacental Insufficiency Alters Liver and Skeletal Muscle Branched-Chain Amino Acid Metabolism in Intrauterine Growth-Restricted Fetal Rats
Uteroplacental insufficiency causes intrauterine growth restriction (IUGR) and decreases plasma levels of the branched-chain… Expand
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Highly Cited
1999
Highly Cited
1999
LAT2, a New Basolateral 4F2hc/CD98-associated Amino Acid Transporter of Kidney and Intestine*
Glycoprotein-associated amino acid transporters (gpaAT) are permease-related proteins that require heterodimerization to express… Expand
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Highly Cited
1998
Highly Cited
1998
Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)*
A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel Na+-independent neutral amino acid… Expand
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