• Publications
  • Influence
The oligopeptide transporter (Pept-1) in human intestine: biology and function.
  • S. Adibi
  • Biology, Medicine
  • Gastroenterology
  • 1 July 1997
The oligopeptide transporter (Pept-1), which is located in the intestinal brush border membrane, provides a major mechanism for protein absorption in the human intestine. Expression cloning of theExpand
  • 300
  • 14
Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease.
  • S. Adibi
  • Medicine, Biology
  • American journal of physiology. Gastrointestinal…
  • 1 November 2003
The abundance of the oligopeptide transporter (Pept-1) in the brush-border membrane of the intestinal epithelium is the central mechanism for regulation of transport of products of protein digestionExpand
  • 190
  • 12
Protein digestion in human intestine as reflected in luminal, mucosal, and plasma amino acid concentrations after meals.
Normal human volunteers were intubated with either aspiration tubes or a biopsy capsule placed in the small intestine. The subjects were then fed a test meal containing 50 g of purified bovine serumExpand
  • 220
  • 9
The high and low affinity transport systems for dipeptides in kidney brush border membrane respond differently to alterations in pH gradient and membrane potential.
The principal aim of the present study was to investigate the effects of variation in proton gradient and membrane potential on the transport of glycyl-L-glutamine (Gly-Gln) by renal brush borderExpand
  • 83
  • 6
Renal assimilation of oligopeptides: physiological mechanisms and metabolic importance.
  • S. Adibi
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 May 1997
Assimilation of systemic oligopeptides (di- and tripeptides) is largely a function of kidneys. The most specific and unique mechanism utilized for the performance of this renal function is transport,Expand
  • 44
  • 5
Determinants of substrate affinity for the oligopeptide/H+ symporter in the renal brush border membrane.
We and others have shown previously the existence of high and low affinity systems for oligopeptide transport in kidney brush border membrane vesicles (BBMV). In the present study we investigated theExpand
  • 85
  • 4
Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption.
  • S. Adibi
  • Medicine
  • The Journal of clinical investigation
  • 1971
A 30 cm segment of the duodenum, jejunum, or ileum of normal human volunteers was perfused, on separate occasions, with test solutions containing either glycylglycine, free glycine, glycylleucine, orExpand
  • 107
  • 4
Transport of beta-lactam antibiotics in kidney brush border membrane. Determinants of their affinity for the oligopeptide/H+ symporter.
  • H. Daniel, S. Adibi
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1 November 1993
This study was designed to determine whether beta-lactam antibiotics (cephalosporins and penicillins) are all substrates for the renal oligopeptide/H+ symporter and, if so, whether the transportExpand
  • 58
  • 4
Hormonal regulation of oligopeptide transporter Pept-1 in a human intestinal cell line.
The intestinal oligopeptide transporter (cloned as Pept-1) has major roles in protein nutrition and drug therapy. A key unstudied question is whether expression of Pept-1 is hormonally regulated. InExpand
  • 107
  • 3
Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast.
The intestinal oligopeptide transporter, cloned as Pept-1, has major roles in the assimilation of dietary proteins and absorption of peptidomimetic medications. The initial aim of the presentExpand
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  • 3