• Publications
  • Influence
Nutritional aspects of manganese homeostasis.
Manganese (Mn) is an essential mineral. It is present in virtually all diets at low concentrations. The principal route of intake for Mn is via food consumption, but in occupational cohorts,Expand
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Roles of the metallothionein family of proteins in the central nervous system
Metallothioneins (MTs) constitute a family of proteins characterized by a high heavy metal [Zn(II), Cu(I)] content and also by an unusual cysteine abundance. Mammalian MTs are comprised of four majorExpand
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Manganese: recent advances in understanding its transport and neurotoxicity.
The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport ofExpand
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Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies.
Neurological disorders are common, costly, and can cause enduring disability. Although mostly unknown, a few environmental toxicants are recognized causes of neurological disorders and subclinicalExpand
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Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
The nematode Caenorhabditis elegans has emerged as an important animal model in various fields including neurobiology, developmental biology, and genetics. Characteristics of this animal model thatExpand
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Manganese Dosimetry: Species Differences and Implications for Neurotoxicity
Abstract Manganese (Mn) is an essential mineral that is found at low levels in food, water, and the air. Under certain high-dose exposure conditions, elevations in tissue manganese levels can occur.Expand
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Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity.
This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findingsExpand
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Manganese: brain transport and emerging research needs.
  • M. Aschner
  • Biology, Medicine
  • Environmental health perspectives
  • 1 June 2000
Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. An estimated 2% of the U.S. population, age 65 and older, develops IPD. The number of IPD patients will certainlyExpand
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Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23 elements that have known physiological functions in humans, 12 are metals, including iron (Fe) and manganese (Mn).Expand
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Brain barrier systems: a new frontier in metal neurotoxicological research.
The concept of brain barriers or a brain barrier system embraces the blood-brain interface, referred to as the blood-brain barrier, and the blood-cerebrospinal fluid (CSF) interface, referred to asExpand
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