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SLC22A3 gene

Known as: SOLUTE CARRIER FAMILY 22 (EXTRANEURONAL MONOAMINE TRANSPORTER), MEMBER 3, EXTRANEURONAL MONOAMINE TRANSPORTER, solute carrier family 22 member 3 
This gene is involved in membrane potential-dependent transport of organic cations.
National Institutes of Health

Related topics

Related topics

9 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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Highly Cited
2017
Highly Cited
2017
RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer
Significance Familial esophageal squamous cell carcinoma (ESCC) often shows early onset and worse prognosis. Little is known… 
Highly Cited
2015
Highly Cited
2015
Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin
Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic… 
Highly Cited
2012
Highly Cited
2012
Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis
One of the central goals of human genetics is to discover the genes and pathways driving human traits. To date, most of the… 
Highly Cited
2011
Highly Cited
2011
Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
Metformin, an oral insulin-sensitizing drug, is actively transported into cells by organic cation transporters (OCT) 1, 2, and 3… 
Highly Cited
2010
Highly Cited
2010
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
Objectives The goals of this study were to determine the role of organic cation transporter 3 (OCT3) in the pharmacological… 
Highly Cited
2009
Highly Cited
2009
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations… 
Highly Cited
2005
Highly Cited
2005
Molecular and functional characterization of an Na+‐independent choline transporter in rat astrocytes
In this study, we examined the molecular and functional characterization of choline uptake into cultured rat cortical astrocytes… 
Highly Cited
2001
Highly Cited
2001
Different action on dopamine catabolic pathways of two endogenous 1,2,3,4‐tetrahydroisoquinolines with similar antidopaminergic properties
The effect of single and multiple 1‐methyl‐1,2,3,4‐tetrahydroisoquinoline (1MeTIQ) and 1‐benzyl‐1,2,3,4‐tetrahydroisoquinoline… 
Highly Cited
1999
Highly Cited
1999
Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.
Here we report the isolation of the mouse and human solute carrier genes Slc22a3/SLC22A3. Slc22a3 is specifically expressed in… 
Highly Cited
1998
Highly Cited
1998
Identity of the Organic Cation Transporter OCT3 as the Extraneuronal Monoamine Transporter (uptake2) and Evidence for the Expression of the Transporter in the Brain*
We investigated the transport of cationic neurotoxins and neurotransmitters by the potential-sensitive organic transporter OCT3… 
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