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Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.
TLDR
Findings indicate that specific CES1 gene variants can lead to clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates. Expand
Clinical Pharmacokinetics of Sertraline
TLDR
Sertraline is a naphthalenamine derivative with the predominant pharmacological action of inhibiting presynaptic reuptake of serotonin from the synaptic cleft that is well tolerated in therapeutic dosages and relatively safe in overdosage. Expand
GREEN TEA (CAMELLIA SINENSIS) EXTRACT DOES NOT ALTER CYTOCHROME P450 3A4 OR 2D6 ACTIVITY IN HEALTHY VOLUNTEERS
TLDR
The results indicate that DGT is unlikely to alter the disposition of medications primarily dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Expand
Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers
TLDR
The results indicate that garlic extracts are unlikely to alter the disposition of coadministered medications primarily dependent on the CYP2D6 or CYP3A4 pathway of metabolism. Expand
In vitro P-glycoprotein affinity for atypical and conventional antipsychotics.
TLDR
The results suggest that P-gp is likely to influence the access to the brain of all of the atypical antipsychotics studied to various degrees, and in vivo studies are needed to confirm these findings. Expand
Drug Glucuronidation in Clinical Psychopharmacology
TLDR
This review summarizes the relevant literature pertaining to drug glucuronidation and its implications for clinical psychopharmacology. Expand
Atypical Antipsychotics Part I: Pharmacology, Pharmacokinetics, and Efficacy
TLDR
Data from controlled trials on efficacy and extrapyramidal side effects support risperidone or olanzapine as first-line agents for the treatment of schizophrenia. Expand
Influence of Ethanol and Gender on Methylphenidate Pharmacokinetics and Pharmacodynamics
TLDR
Women reported a significantly greater stimulant effect than men when questioned “Do you feel any drug effect?” (P<0.05), in spite of lower mean plasma d‐MPH area under the response–time curves in women. Expand
Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana
TLDR
It is indicated that CBD significantly inhibits P-gp-mediated drug transport, suggesting CBD could potentially influence the absorption and disposition of other coadministered compounds that are P- gp substrates. Expand
Advances in the Pharmacotherapy of Attention‐Deficit‐Hyperactivity Disorder: Focus on Methylphenidate Formulations
The psychostimulant dl‐methylphenidate (MPH) remains the most common drug therapy in child and adolescent psychiatry for the treatment of attention‐deficit‐hyperactivity disorder (ADHD). Evidence ofExpand
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