Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.
- J. Lenders, Q. Duh, W. Young
- MedicineJournal of Clinical Endocrinology and Metabolism
- 3 June 2014
This evidence-based guideline recommends minimally invasive adrenalectomy for most pheochromocytomas with open resection for most paragangliomas and suggests personalized management with evaluation and treatment by multidisciplinary teams with appropriate expertise to ensure favorable outcomes.
Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
- G. Eisenhofer, I. Kopin, D. Goldstein
- Biology, ChemistryPharmacological Reviews
- 1 September 2004
The large contribution of intraneuronal deamination to catecholamine turnover, and dependence of this on the vesicular-axoplasmic monoamine exchange process, helps explain how synthesis, release, metabolism, turnovers, and stores of catechlamines are regulated in a coordinated fashion during stress and in disease states.
Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions.
- M. Esler, G. Jennings, G. Lambert, I. Meredith, M. Horne, G. Eisenhofer
- Chemistry, MedicinePhysiological Reviews
- 1 October 1990
Article de synthese sur l'efflux des neurotransmetteurs catecholaminergiques chez les mammiferes d'augmentation du mode de decharge des nerfs sympathiques vers la circulation.
Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans
- D. Goldstein, G. Eisenhofer, I. Kopin
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 June 2003
Human plasma contains several catechols, including the catecholamines norepinephrine, epinephrine, and dopamine, their precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), and their deaminated…
Biochemical diagnosis of pheochromocytoma: which test is best?
- J. Lenders, K. Pacak, G. Eisenhofer
- Medicine, BiologyJAMA
- 20 March 2002
Plasma free metanephrines provide the best test for excluding or confirming pheochromocytoma and should be the test of first choice for diagnosis of the tumor.
Recent Advances in Genetics, Diagnosis, Localization, and Treatment of Pheochromocytoma
- K. Pacak, W. Linehan, G. Eisenhofer, McClellan Walther, D. Goldstein
- Medicine, BiologyAnnals of Internal Medicine
- 20 February 2001
Advances in genetic mutation analysis have greatly improved identification of patients with familial pheochromocytoma, allowing detection of tumors at an early stage, often before typical signs and symptoms occur and highlighting inadequacies of commonly used diagnostic tests.
The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines.
- G. Eisenhofer
- BiologyPharmacology and Therapeutics
- 1 July 2001
Pheochromocytoma: recommendations for clinical practice from the First International Symposium
- K. Pacak, G. Eisenhofer, A. Tischler
- Medicine, BiologyNature Clinical Practice Endocrinology…
- 1 February 2007
Recommendations were made during the symposium for biochemical diagnosis, localization, genetics, and treatment of Pheochromocytoma that inadequate methods to distinguish malignant from benign tumors and a lack of effective treatments for malignancy are important problems requiring further resolution.
Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results.
- G. Eisenhofer, D. Goldstein, K. Pacak
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 June 2003
In patients with suspected pheochromocytoma and positive biochemical results, false-positive elevations due to medications should first be eliminated and patterns of biochemical test results and responses of plasma normetanephrine to clonidine can then help distinguish true- from false- positive results.
Malignant pheochromocytoma: current status and initiatives for future progress.
- G. Eisenhofer, S. Bornstein, W. Young
- Medicine, BiologyEndocrine-Related Cancer
- 1 September 2004
The well-characterized hereditary basis and the unique functional nature of these neuroendocrine tumors provide a useful framework that offers advantages for establishing the pathways of tumorigenesis and malignancy.