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SHR, Rat Strain

Known as: SHR 
SHR: rats develop hypertension spontaneously without exception at the age of 7-15 weeks. There is a systolic blood pressure plateau of about 200 mmHg… 
National Institutes of Health

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2002
Highly Cited
2002
Expression and Cellular Localization of Classic NADPH Oxidase Subunits in the Spontaneously Hypertensive Rat Kidney
Phagocytes generate superoxide anion (O2−) by a classic, 5-component NADPH oxidase. O2− contributes to hypertension in… 
Highly Cited
1998
Highly Cited
1998
Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates… 
Highly Cited
1998
Highly Cited
1998
Alterations of nitric oxide synthase expression with aging and hypertension in rats.
The activity and protein expression of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) were investigated during… 
Highly Cited
1995
Highly Cited
1995
In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography.
The factors that predispose to the accelerated organ injury that accompanies the hypertensive syndrome have remained speculative… 
Highly Cited
1994
Highly Cited
1994
Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.
The failing heart is characterized by impaired cardiac muscle function and increased interstitial fibrosis. Our purpose was to… 
Highly Cited
1991
Highly Cited
1991
Cardioreparative Effects of Lisinopril in Rats With Genetic Hypertension and Left Ventricular Hypertrophy
BackgroundIn genetic and acquired hypertension, a structural remodeling of the nonmyocyte compartment of the myocardium… 
Highly Cited
1987
Highly Cited
1987
Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats.
Spontaneously hypertensive rats (SHR) and normotensive control, Wistar/Kyoto (WKY) rats through two generations were fed a… 
Highly Cited
1983
Highly Cited
1983
Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.
The possible role of endothelium in the vascular responses to vasodilator drugs was studied in relation to experimental… 
Highly Cited
1976
Highly Cited
1976
Sympathetic Nerve Activity: Role in Regulation of Blood Pressure in the Spontaneously Hypertensive Rat
Sympathetic nerve activity (SNA) and high pressure baroreceptor regulation of SNA were studied in the Okamoto strain of… 
Highly Cited
1974
Highly Cited
1974
Blood pressure changes produced by kidney cross-transplantation between spontaneously hypertensive rats and normotensive rats.
1. From a single strain of Wistar rats two lines of normotensive rats (NR) and two lines of hypertensive rats (SHR) were… 
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