SHR, Rat Strain

Known as: SHR 
SHR: rats develop hypertension spontaneously without exception at the age of 7-15 weeks. There is a systolic blood pressure plateau of about 200 mmHg… (More)
National Institutes of Health

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Review
2016
Review
2016
Animal models of metabolic syndrome: a review
Metabolic syndrome (MetS) consists of several medical conditions that collectively predict the risk for cardiovascular disease… (More)
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Highly Cited
2005
Highly Cited
2005
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin.
In the spontaneously hypertensive rat (SHR) and aging Wistar-Kyoto rats (WKY), acetylcholine releases an endothelium-derived… (More)
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Highly Cited
2001
Highly Cited
2001
Intercellular movement of the putative transcription factor SHR in root patterning
Positional information is pivotal for establishing developmental patterning in plants, but little is known about the underlying… (More)
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Review
2000
Review
2000
Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD)
A good model of a disorder is one that: (a) mimics, although in a simpler form than the full-blown clinical case, the… (More)
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Highly Cited
2000
Highly Cited
2000
The SHORT-ROOT Gene Controls Radial Patterning of the Arabidopsis Root through Radial Signaling
Asymmetric cell divisions play an important role in the establishment and propagation of the cellular pattern of plant tissues… (More)
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Highly Cited
1998
Highly Cited
1998
Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates… (More)
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Highly Cited
1997
Highly Cited
1997
A multiple-test study of anxiety-related behaviours in six inbred rat strains
Recent studies have underlined the impact of genetic factors in anxiety profiles. In this context, we have initiated a series of… (More)
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Highly Cited
1995
Highly Cited
1995
A genetic linkage map of the laboratory rat, Rattus norvegicus
We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence… (More)
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Highly Cited
1991
Highly Cited
1991
Does superoxide underlie the pathogenesis of hypertension?
Although active oxygen species play important roles in the pathogenesis of various diseases, the molecular mechanism for oxygen… (More)
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Highly Cited
1986
Highly Cited
1986
Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.
To study the mechanism of decreased endothelium-dependent relaxations in spontaneously hypertensive rats (SHR), rings of thoracic… (More)
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