• Publications
  • Influence
The vasodilator role of adenosine.
  • M. Collis
  • Medicine
  • Pharmacology & therapeutics
  • 1989
In this article, the evidence in favor of a vasodilator role for endogenous adenosine in heart, brain and skeletal muscle is critically reviewed, together with the current views on the cellularExpand
  • 121
  • 5
The role of adenosine in exercise hyperaemia of the gracilis muscle in anaesthetized cats.
1. A number of metabolites have been proposed to control the vascular tone of skeletal muscle during exercise. The present study was designed to investigate the role of adenosine in this response byExpand
  • 51
  • 3
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.
6-Cyclohexyl-N-hydroxy-3-(1,2,4-oxadiazol-5-yl)hexanamides were previously disclosed as inhibitors of procollagen C-proteinase (PCP) culminating in the identification of amide 1. Our objective was toExpand
  • 43
  • 3
Vascular reactivity of isolated perfused kidneys from male and female spontaneously hypertensive rats.
SUMMARY We investigated vascular reactivity in isolated, Tyrode perfused kidneys from male (blood pressure, 222.6 mm Hg) and female (blood pressure, 178.5 mm Hg) spontaneously hypertensive rats (SHR,Expand
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  • PDF
Epinephrine enhances neurogenic vasoconstriction in the rat perfused kidney.
Epinephrine has been implicated in the genesis of some forms of hypertension. We have investigated the effects of epinephrine on vasoconstrictor responses evoked by adrenergic stimuli in the isolatedExpand
  • 30
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The effect of alpha 1 adrenoceptor antagonist prazosin on capillary supply, blood flow and performance in a rat model of chronic muscle ischaemia.
OBJECTIVE This study explores whether the a1 blocker prazosin improves capillarisation, blood flow and muscle performance in chronically ischaemic muscles. DESIGN Rat skeletal muscles were madeExpand
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Interaction of angiotensin-converting enzyme inhibitors with the function of the sympathetic nervous system.
Abstract The effects of the converting enzyme inhibitors captopril and SQ 20881 and the angiotensin II antagonist saralasin were studied on neurogenic vasoconstriction in the rat using both in vivoExpand
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Hypotensive Action of Captopril in Spontaneously Hypertensive and Normotensive Rats Interference with Neurogenic Vasoconstriction
The effects of captopril and angiotensin II on adrenergic neurotransmission have been studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). In a pithed rat preparation,Expand
  • 48
  • 1
  • PDF
Vascular reactivity to vasopressin in doca‐salt hypertensive rats
  • M. Collis
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1 September 1981
the results of Schneider & Drazen (1980). Since PGI, was described as a pulmonary vasodilator (Kadowitz et a1 1978), the contribution of vascular smooth muscles to the myotropic activity of the lungExpand
  • 10
  • 1
Evidence for an Ax‐adenosine receptor in the guinea‐pig atrium
  • M. Collis
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1 January 1983
1 The purpose of this study was to determine whether the adenosine receptor that mediates a decrease in the force of contraction of the guinea‐pig atrium is of the A1‐ or A2‐sub‐type. 2Expand
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