• Publications
  • Influence
EDHF: bringing the concepts together.
TLDR
Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization and the main concepts are considered in detail in this review. Expand
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture).
Endothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial dysfunction has beenExpand
Endothelium-Derived Hyperpolarizing Factor: Where Are We Now?
TLDR
The endothelium controls vascular tone not only by releasing nitric oxide and prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth muscle cells, which can be evoked by direct electrical coupling through myo-endothelial junctions and/or the accumulation of potassium ions in the intercellular space. Expand
Endothelial dysfunction in diabetes
TLDR
Correcting the principal mediators of hyperglycaemia‐induced endothelial dysfunction may be activation of protein kinase C, increased activity of the polyol pathway, non‐enzymatic glycation and oxidative stress, as well as administration of ACE inhibitors and folate has been shown to improve endothelium‐dependent vasodilation in diabetes. Expand
Acetylcholine‐induced endothelium‐dependent contractions in the SHR aorta: the Janus face of prostacyclin
TLDR
In the aorta of SHR and aging WKY, the endothelium‐dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2. Expand
Endothelial dysfunction and vascular disease
TLDR
The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances, which are reduced in the course of vascular disease and selectively loose the pertussis toxin‐sensitive pathway for NO release which favours vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis. Expand
Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP.
TLDR
Normal vascular homeostasis depends in the periphery on a balance between neurally and humorally mediated vasoconstriction in skeletal muscle, mesentery, and the kidney, and local endothelium-dependent vasodilatation. Expand
Endothelial dysfunction and vascular disease.
  • P. Vanhoutte
  • Medicine
  • Verhandelingen - Koninklijke Academie voor…
  • 1998
TLDR
In blood vessels from animals with regenerated endothelium, and/or atherosclerosis, there is a selective loss of the pertussis-toxin sensitive mechanism of EDRF-release which favors the occurrence of vasospasm, thrombosis and cellular growth. Expand
Endothelial dysfunction: the first step toward coronary arteriosclerosis.
  • P. Vanhoutte
  • Medicine
  • Circulation journal : official journal of the…
  • 20 March 2009
The endothelium causes relaxations of the underlying vascular smooth muscle, by releasing nitric oxide (NO). The endothelial cells also can evoke hyperpolarization of the vascular smooth muscle cellsExpand
Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products
TLDR
Since in most cases, the activation of TP receptors is the common downstream effector, selective antagonists of this receptor should curtail endothelial dysfunction and be of therapeutic interest in the treatment of cardiovascular disorders. Expand
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