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EDHF: bringing the concepts together.
Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture).
Endothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial dysfunction has been…
Endothelial dysfunction in diabetes
- A. D. De Vriese, T. Verbeuren, J. van de Voorde, N. Lameire, P. Vanhoutte
- Medicine, BiologyBritish Journal of Pharmacology
- 1 July 2000
Correcting the principal mediators of hyperglycaemia‐induced endothelial dysfunction may be activation of protein kinase C, increased activity of the polyol pathway, non‐enzymatic glycation and oxidative stress, as well as administration of ACE inhibitors and folate has been shown to improve endothelium‐dependent vasodilation in diabetes.
Endothelium-Derived Hyperpolarizing Factor: Where Are We Now?
The endothelium controls vascular tone not only by releasing nitric oxide and prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth muscle cells, which can be evoked by direct electrical coupling through myo-endothelial junctions and/or the accumulation of potassium ions in the intercellular space.
Acetylcholine‐induced endothelium‐dependent contractions in the SHR aorta: the Janus face of prostacyclin
- P. Gluais, M. Lonchampt, J. Morrow, P. Vanhoutte, M. Félétou
- Biology, MedicineBritish Journal of Pharmacology
- 1 November 2005
In the aorta of SHR and aging WKY, the endothelium‐dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2.
Endothelial dysfunction and vascular disease.
- P. Vanhoutte
- Biology, MedicineVerhandelingen - Koninklijke Academie voor…
In blood vessels from animals with regenerated endothelium, and/or atherosclerosis, there is a selective loss of the pertussis-toxin sensitive mechanism of EDRF-release which favors the occurrence of vasospasm, thrombosis and cellular growth.
Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP.
Normal vascular homeostasis depends in the periphery on a balance between neurally and humorally mediated vasoconstriction in skeletal muscle, mesentery, and the kidney, and local endothelium-dependent vasodilatation.
Endothelial dysfunction: the first step toward coronary arteriosclerosis.
- P. Vanhoutte
- Biology, MedicineCirculation Journal
- 20 March 2009
Endothelium dysfunction is the first step toward coronary arteriosclerosis.