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Binding of angiotensin and atrial natriuretic peptide in brain of hypertensive rats
- J. Saavedra, F. Corrêa, L. Plunkett, A. Israel, M. Kurihara, K. Shigematsu
- Biology, MedicineNature
- 24 April 1986
A central role for rANP and AII in genetic hypertension is suggested; they may act as mutual antagonists in brain areas involved in control of blood pressure and fluid regulation.
Increased number of angiotensin II receptors in the subfornical organ of spontaneously hypertensive rats.
- J. Saavedra, F. Corrêa, M. Kurihara, K. Shigematsu
- Biology, ChemistryJournal of hypertension. Supplement : official…
- 1 December 1986
The results suggest that subfornical organ angiotensin II receptors are involved in genetic hypertension in the rat and substantiates the idea of an overactive central angiotENSin II system in spontaneous hypertension.
Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats.
In SHR, alteration in Ang II binding is restricted to brain nuclei involved in the central pressor action of Ang II and seems to be related to the development and maintenance of spontaneous hypertension.
Alteration of atrial natriuretic peptide binding sites in spontaneously hypertensive rats.
The SHRs have notable tissue specific decrease in ANP binding site concentration, which may relate to the pathophysiology of genetic hypertension.
Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats.
The results suggest that increased Angiotensin II receptors in selected brain areas may play a role in the pathophysiology of mineralocorticoid-salt experimental hypertension.
Localization and characterization of atrial natriuretic peptide binding sites in discrete areas of rat brain and pituitary gland by quantitative autoradiography
Atrial natriuretic peptide, ANP(99-126), receptors in rat thymocytes and spleen cells.
Receptor autoradiographic localization of insulin-like growth factor-I (IGF-I) binding sites in human fetal and adult adrenal glands.
Specific binding sites for 125I-endothelin-1 in the porcine and human spinal cord.
Receptor autoradiographic analysis of insulin-like growth factor-I (IGF-I) binding sites in rat forebrain and pituitary gland
Noteworthy was the difference in the potency of insulin in inhibiting the binding among the areas examined, a finding which suggests heterogeneity of IGF-I receptors.