SETDB1 protein, human

Known as: Histone-Lysine N-Methyltransferase SETDB1, SET Domain Bifurcated 1, Lysine N-Methyltransferase 1E 
Histone-lysine N-methyltransferase SETDB1 (1291 aa, ~143 kDa) is encoded by the human SETDB1 gene. This protein is involved in histone methylation.
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Epithelial-mesenchymal transition (EMT) contributes to tumor invasion and metastasis in many cancers and correlates highly with… (More)
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Highly Cited
2011
Highly Cited
2011
The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity… (More)
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Highly Cited
2011
Highly Cited
2011
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing of genes and retroelements… (More)
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Highly Cited
2010
Highly Cited
2010
Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are… (More)
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Highly Cited
2010
Highly Cited
2010
Lysine 9 of histone 3 (H3K9) can be mono-, di-, or trimethylated, inducing distinct effects on gene expression and chromatin… (More)
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Highly Cited
2009
Highly Cited
2009
Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin… (More)
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2007
2007
Histone H3 lysine 9 (H3K9) methylation is associated with gene repression and heterochromatin formation. In Drosophila, SU(VAR)3… (More)
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Highly Cited
2006
Highly Cited
2006
DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in heterochromatin formation and gene silencing… (More)
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Highly Cited
2004
Highly Cited
2004
In mammals, heterochromatin is characterized by DNA methylation at CpG dinucleotides and methylation at lysine 9 of histone H3… (More)
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Highly Cited
2002
Highly Cited
2002
Posttranslational modification of histones has emerged as a key regulatory signal in eukaryotic gene expression. Recent genetic… (More)
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