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SETDB1 protein, human
Known as:
Histone-Lysine N-Methyltransferase SETDB1
, SET Domain Bifurcated 1
, Lysine N-Methyltransferase 1E
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Histone-lysine N-methyltransferase SETDB1 (1291 aa, ~143 kDa) is encoded by the human SETDB1 gene. This protein is involved in histone methylation.
National Institutes of Health
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Related topics
Related topics
15 relations
DOT1L wt Allele
Enzyme Gene
Gene Expression
Methylation
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Broader (1)
Protein Methyltransferases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery
Benjamin D. Towbin
,
Cristina González-Aguilera
,
+5 authors
S. Gasser
Cell
2012
Corpus ID: 3174646
Highly Cited
2011
Highly Cited
2011
The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma
C. Ceol
,
Y. Houvras
,
+19 authors
L. Zon
Nature
2011
Corpus ID: 115211967
The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity…
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Highly Cited
2010
Highly Cited
2010
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET
T. Matsui
,
D. Leung
,
+6 authors
Y. Shinkai
Nature
2010
Corpus ID: 4422359
Endogenous retroviruses (ERVs), retrovirus-like elements with long terminal repeats, are widely dispersed in the euchromatic…
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Review
2010
Review
2010
KAP1 controls endogenous retroviruses in embryonic stem cells
Helen M. Rowe
,
Johan Jakobsson
,
+10 authors
D. Trono
Nature
2010
Corpus ID: 4323449
More than forty per cent of the mammalian genome is derived from retroelements, of which about one-quarter are endogenous…
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Review
2009
Review
2009
Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis
I. Takada
,
A. Kouzmenko
,
S. Kato
Nature Reviews Rheumatology
2009
Corpus ID: 37518703
Osteoblasts and adipocytes differentiate from a common pluripotent precursor, the mesenchymal stem cell (MSC). Studies have…
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Highly Cited
2009
Highly Cited
2009
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.
S. Bilodeau
,
M. Kagey
,
G. Frampton
,
P. Rahl
,
R. Young
Genes & Development
2009
Corpus ID: 30324998
Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin…
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Highly Cited
2006
Highly Cited
2006
The Histone Methyltransferase SETDB1 and the DNA Methyltransferase DNMT3A Interact Directly and Localize to Promoters Silenced in Cancer Cells*
Hongwei Li
,
T. Rauch
,
Zhao-xia Chen
,
P. Szabó
,
A. Riggs
,
G. Pfeifer
Journal of Biological Chemistry
2006
Corpus ID: 7497849
DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in heterochromatin formation and gene silencing…
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Highly Cited
2006
Highly Cited
2006
The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression
S. Sripathy
,
J. Stevens
,
D. C. Schultz
Molecular and Cellular Biology
2006
Corpus ID: 20923421
ABSTRACT KAP1/TIF1β is proposed to be a universal corepressor protein for the KRAB zinc finger protein (KRAB-zfp) superfamily of…
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Highly Cited
2004
Highly Cited
2004
Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly.
Shireen A. Sarraf
,
I. Stancheva
Molecules and Cells
2004
Corpus ID: 37263640
Highly Cited
2002
Highly Cited
2002
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
D. C. Schultz
,
K. Ayyanathan
,
D. Negorev
,
G. Maul
,
F. Rauscher
Genes & Development
2002
Corpus ID: 23901400
Posttranslational modification of histones has emerged as a key regulatory signal in eukaryotic gene expression. Recent genetic…
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